ArticleRNA (New York, N.Y.)2005
Ribavirin is not a functional mimic of the 7-methyl guanosine mRNA cap.
Article in RNA (New York, N.Y.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Review
- Chemical Probes for Studying the Eukaryotic Translation Initiation Factor 4E (eIF4E)-Regulated Translatome in Cancer.ACS pharmacology & translational science · 2025Review
- eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production.Nucleus (Austin, Tex.) · 2024Review
- Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy.Microorganisms · 2022Review
- Targeting mTOR and eIF4E: a feasible scenario in ovarian cancer therapy.Cancer drug resistance (Alhambra, Calif.) · 2021Review
- A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesis.Biochemistry. Biokhimiia · 2020Review
- Cancer the'RBP'eutics-RNA-binding proteins as therapeutic targets for cancer.Pharmacology & therapeutics · 2019Review
- eIF4E-Dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity.Frontiers in genetics · 2018Review
- Mutagenic Effects of Ribavirin on Hepatitis E Virus-Viral Extinction versus Selection of Fitness-Enhancing Mutations.Viruses · 2016Review
- The eukaryotic translation initiation factor eIF4E wears a "cap" for many occasions.Translation (Austin, Tex.) · 2016Article
- Targeting the translation machinery in cancer.Nature reviews. Drug discovery · 2015Review
- Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.Cancer research · 2015Review
- The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer.Advances in protein chemistry and structural biology · 2015Review
- Targeting translation initiation in breast cancer.Translation (Austin, Tex.) · 2014Review
- The immunosuppressive agent mizoribine monophosphate is an inhibitor of the human RNA capping enzyme.PloS one · 2013Article
- Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target.Medicinal research reviews · 2012Review
- Attacking a nexus of the oncogenic circuitry by reversing aberrant eIF4F-mediated translation.Molecular cancer therapeutics · 2012Review
- Oncogenic AKTivation of translation as a therapeutic target.British journal of cancer · 2011Review
- The biological and therapeutic relevance of mRNA translation in cancer.Nature reviews. Clinical oncology · 2011Review
Corrections and comments
- Commented on by
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ribavirin is a guanosine ribonucleoside analog that displays broad-spectrum anti-viral activity and is currently used for the treatment of some viral infections. Ribavirin has recently been proposed to also be a mimic of the 7-methyl guanosine cap found at the 5' end of mRNAs. To obtain supporting functional data for this hypothesis, we assessed the ability of ribavirin triphosphate to interfere with the interaction between eIF4E and 7-methyl guanosine capped mRNA. In chemical cross-linking assays, cap-affinity chromatography, and cap-dependent translation assays, ribavirin was unable to function as a cap analog.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.