Trial reportBMC public health2005
Psychophysiological effects of a web-based stress management system: a prospective, randomized controlled intervention study of IT and media workers [ISRCTN54254861].
Trial report in BMC public health, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 9 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Optimizing Workplace Digital Mental Health Interventions: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Trends in Effectiveness of Organizational eHealth Interventions in Addressing Employee Mental Health: Systematic Review and Meta-analysis.Journal of medical Internet research · 2022Pooled it
- Associations of working conditions and chronic low-grade inflammation among employees: a systematic review and meta-analysis.Scandinavian journal of work, environment & health · 2021Pooled it
- Psychosocial Interventions and Immune System Function: A Systematic Review and Meta-analysis of Randomized Clinical Trials.JAMA psychiatry · 2020Pooled it
- Computer-based versus in-person interventions for preventing and reducing stress in workers.The Cochrane database of systematic reviews · 2017Pooled it
- The Benefit of Web- and Computer-Based Interventions for Stress: A Systematic Review and Meta-Analysis.Journal of medical Internet research · 2017Pooled it
- Effectiveness of eHealth interventions for reducing mental health conditions in employees: A systematic review and meta-analysis.PloS one · 2017Pooled it
- What is actually measured in process evaluations for worksite health promotion programs: a systematic review.BMC public health · 2013Pooled it
- Media-delivered cognitive behavioural therapy and behavioural therapy (self-help) for anxiety disorders in adults.The Cochrane database of systematic reviews · 2013Pooled it
- Trial
- Effects of a Web-Based Intervention for Stress Reduction in Primary Care: A Cluster Randomized Controlled Trial.Journal of medical Internet research · 2016Trial
- Long-term results of a web-based guided self-help intervention for employees with depressive symptoms: randomized controlled trial.Journal of medical Internet research · 2014Trial
- Efficacy and cost-effectiveness of a web-based and mobile stress-management intervention for employees: design of a randomized controlled trial.BMC public health · 2013Trial
- Multilevel growth curve analyses of treatment effects of a Web-based intervention for stress reduction: randomized controlled trial.Journal of medical Internet research · 2013Trial
- Cognitively oriented behavioral rehabilitation in combination with Qigong for patients on long-term sick leave because of burnout: REST--a randomized clinical trial.International journal of behavioral medicine · 2009Trial
- Self-reported health and health literacy, neuroplasticity and neuro-immunological markers during the first 12 months in newly diagnosed people living with HIV: An exploratory study.Brain, behavior, & immunity - health · 2026Article
- The prospective relationship between uptake of earned income tax credit (EITC), financial strain, and health in socio-economically strained families of Arab-American descent.BMC public health · 2026Article
- Article
- Relationship between Stress and Neuroimmunological Responses and Health Literacy in Newly Diagnosed HIV-Infected Patients: An Exploratory Study.AIDS research and treatment · 2024Article
- Evaluating the feasibility and exploring the efficacy of an emotion-based approach-avoidance modification training (eAAMT) in the context of perceived stress in an adult sample - protocol of a parallel randomized controlled pilot study.Pilot and feasibility studies · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the present study was to assess possible effects on mental and physical well-being and stress-related biological markers of a web-based health promotion tool.
methodsA randomized, prospectively controlled study was conducted with before and after measurements, involving 303 employees (187 men and 116 women, age 23-64) from four information technology and two media companies. Half of the participants were offered web-based health promotion and stress management training (intervention) lasting for six months. All other participants constituted the reference group. Different biological markers were measured to detect possible physiological changes.
resultsAfter six months the intervention group had improved statistically significantly compared to the reference group on ratings of ability to manage stress, sleep quality, mental energy, concentration ability and social support. The anabolic hormone dehydroepiandosterone sulphate (DHEA-S) decreased significantly in the reference group as compared to unchanged levels in the intervention group. Neuropeptide Y (NPY) increased significantly in the intervention group compared to the reference group. Chromogranin A (CgA) decreased significantly in the intervention group as compared to the reference group. Tumour necrosis factor alpha (TNFalpha) decreased significantly in the reference group compared to the intervention group. Logistic regression analysis revealed that group (intervention vs. reference) remained a significant factor in five out of nine predictive models.
conclusionThe results indicate that an automatic web-based system might have short-term beneficial physiological and psychological effects and thus might be an opportunity in counteracting some clinically relevant and common stress and health issues of today.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.