Trial reportAddiction (Abingdon, England)2005
A multi-center randomized trial of buprenorphine-naloxone versus clonidine for opioid detoxification: findings from the National Institute on Drug Abuse Clinical Trials Network.
Trial report in Addiction (Abingdon, England), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 118 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pharmacological therapies for management of opium withdrawal.The Cochrane database of systematic reviews · 2018Pooled it
- Buprenorphine for managing opioid withdrawal.The Cochrane database of systematic reviews · 2017Pooled it
- Research on the diffusion of evidence-based treatments within substance abuse treatment: a systematic review.Journal of substance abuse treatment · 2009Pooled it
- Trial
- Buprenorphine in the emergency department: Randomized clinical controlled trial of clonidine versus buprenorphine for the treatment of opioid withdrawal.Canadian family physician Medecin de famille canadien · 2019Trial
- NIDA Clinical Trials Network CTN-0051, Extended-Release Naltrexone vs. Buprenorphine for Opioid Treatment (X:BOT): Study design and rationale.Contemporary clinical trials · 2016Trial
- Buprenorphine Initiation and Linkage to Outpatient Buprenorphine do not Reduce Frequency of Injection Opiate Use Following Hospitalization.Journal of substance abuse treatment · 2016Trial
- Buprenorphine + naloxone plus naltrexone for the treatment of cocaine dependence: the Cocaine Use Reduction with Buprenorphine (CURB) study.Addiction (Abingdon, England) · 2016Trial
- Pain volatility and prescription opioid addiction treatment outcomes in patients with chronic pain.Experimental and clinical psychopharmacology · 2015Trial
- Characterizing opioid withdrawal during double-blind buprenorphine detoxification.Drug and alcohol dependence · 2015Trial
- Opioid withdrawal, craving, and use during and after outpatient buprenorphine stabilization and taper: a discrete survival and growth mixture model.Addictive behaviors · 2015Trial
- A randomized pilot clinical trial to evaluate the efficacy of Community Reinforcement and Family Training for Treatment Retention (CRAFT-T) for improving outcomes for patients completing opioid detoxification.Drug and alcohol dependence · 2014Trial
- Psychometric properties of the adjective rating scale for withdrawal across treatment groups, gender, and over time.Journal of substance abuse treatment · 2014Trial
- Comparison of behavioral treatment conditions in buprenorphine maintenance.Addiction (Abingdon, England) · 2013Trial
- Predictors of outcome after short-term stabilization with buprenorphine.Journal of substance abuse treatment · 2013Trial
- A stage I pilot study of acceptance and commitment therapy for methadone detoxification.Drug and alcohol dependence · 2012Trial
- Adjunctive counseling during brief and extended buprenorphine-naloxone treatment for prescription opioid dependence: a 2-phase randomized controlled trial.Archives of general psychiatry · 2011Trial
- Clinical correlates of health-related quality of life among opioid-dependent patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2011Trial
- Participant characteristics and buprenorphine dose.The American journal of drug and alcohol abuse · 2011Trial
- HIV risk behavior in treatment-seeking opioid-dependent youth: results from a NIDA clinical trials network multisite study.Journal of acquired immune deficiency syndromes (1999) · 2010Trial
58 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
16 authors.
Funding
Abstract
aimsThe clinical effectiveness of buprenorphine-naloxone (bup-nx) and clonidine for opioid detoxification in in-patient and out-patient community treatment programs was investigated in the first studies of the National Institute of Drug Abuse Clinical Trials Network.
designDiagnostic and Statistical Manual version IV (DSM IV)-diagnosed opioid-dependent individuals seeking short-term treatment were randomly assigned, in a 2 : 1 ratio favoring bup-nx, to a 13-day detoxification using bup-nx or clonidine.
methodsA total of 113 in-patients (77 bup-nx, 36 clonidine) and 231 out-patients (157 bup-nx, 74 clonidine) participated. Supportive interventions included appropriate ancillary medications and standard counseling procedures guided by a self-help handbook. The criterion for treatment success was defined as the proportion of participants in each condition who were both retained in the study for the entire duration and provided an opioid-free urine sample on the last day of clinic attendance. Secondary outcome measures included use of ancillary medications, number of side effects reported and withdrawal and craving ratings.
findingsA total of 59 of the 77 (77%) in-patients assigned to the bup-nx condition achieved the treatment success criterion compared to eight of the 36 (22%) assigned to clonidine, whereas 46 of the 157 (29%) out-patients assigned to the bup-nx condition achieved the treatment success criterion, compared to four of the 74 (5%) assigned to clonidine.
conclusionThe benefits of bup-nx for opioid detoxification are supported and illustrate important ways in which clinical research can be conducted in community treatment programs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.