Trial reportEuropean journal of nuclear medicine and molecular imaging2006
Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina.
Trial report in European journal of nuclear medicine and molecular imaging, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Imaging of myocardial fatty acid oxidation.Biochimica et biophysica acta · 2016Review
- Ischaemic memory imaging using metabolic radiopharmaceuticals: overview of clinical settings and ongoing investigations.European journal of nuclear medicine and molecular imaging · 2014Review
- Metabolic imaging using SPECT.European journal of nuclear medicine and molecular imaging · 2007Review
- Diagnostic and prognostic value of BMIPP imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2007Review
- Nuclear cardiology in the literature.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2006Article
- Myocardial ischaemia and metabolic memory.European journal of nuclear medicine and molecular imaging · 2006Article
- The Japanese experience with metabolic imaging in the clinical setting.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyReview
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLong-chain fatty acid (LCFA) is the main energy source for normal myocardium at rest, but in ischemic myocardium, the main energy substrate shifts from LCFA to glucose. 123I-BMIPP is a radiolabeled LCFA analog. In chronic stable angina without previous infarction, we suppose that reduced 123I-BMIPP uptake is related to the substrate shift in myocardium with decreased myocardial flow reserve (MFR). The purpose of this study was to relate 123I-BMIPP uptake to rest myocardial blood flow (MBF), hyperemic MBF, and MFR assessed with 15O-water positron emission tomography (PET).
methodsWe enrolled 21 patients with chronic stable angina without previous infarction, all of whom underwent 123I-BMIPP single-photon emission computed tomography (SPECT) and 15O-water PET. The left ventricle was divided into 13 segments. In each segment, rest MBF and hyperemic MBF were measured by PET. 123I-BMIPP uptake was evaluated as follows: score 0=normal, 1=slightly decreased uptake, 2=moderately decreased uptake, 3=severely decreased uptake, and 4=complete defect. 123I-BMIPP uptake was compared with rest MBF, hyperemic MBF, and MFR.
resultsThe numbers of segments with 123I-BMIPP scores 0, 1, 2, 3, and 4 were 178, 40, 25, 24, and 0, respectively. The rest MBFs for scores 0, 1, 2, and 3 were 0.93+/-0.25, 0.86+/-0.21, 0.97+/-0.30, and 0.99+/-0.37 ml/min/g, respectively. The hyperemic MBFs for scores 0, 1, 2, and 3 were 2.76+/-1.29, 1.84+/-0.74, 1.37+/-0.39, and 1.08+/-0.40 ml/min/g, respectively. The MFRs for scores 0, 1, 2, and 3 were 3.01+/-1.38, 2.20+/-0.95, 1.44+/-0.22, and 1.10+/-0.26, respectively. As 123I-BMIPP uptake declined, hyperemic MBF and MFR decreased.
conclusionIn chronic stable angina without previous infarction, reduced 123I-BMIPP uptake implies decreased MFR.
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