ReviewPsychopharmacology2005
Phenotypic studies on dopamine receptor subtype and associated signal transduction mutants: insights and challenges from 10 years at the psychopharmacology-molecular biology interface.
Review in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Article
- The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model.Disease models & mechanisms · 2016Article
- Dopamine D1 Receptor-Mediated Transmission Maintains Information Flow Through the Cortico-Striato-Entopeduncular Direct Pathway to Release Movements.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Distinct motor impairments of dopamine D1 and D2 receptor knockout mice revealed by three types of motor behavior.Frontiers in integrative neuroscience · 2014Article
- Dopamine D4 receptors in psychostimulant addiction.Advances in pharmacology (San Diego, Calif.) · 2014Review
- D-amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Disease-specific heteromerization of G-protein-coupled receptors that target drugs of abuse.Progress in molecular biology and translational science · 2013Review
- Adenosine A2A receptor gene disruption protects in an α-synuclein model of Parkinson's disease.Annals of neurology · 2012Article
- Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Neurogenetics and pharmacology of learning, motivation, and cognition.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Review
- Agonistic behavior in males and females: effects of an estrogen receptor beta agonist in gonadectomized and gonadally intact mice.Psychoneuroendocrinology · 2010Article
- Genetic analysis of sleep.Genes & development · 2010Review
- Mutant mouse models: genotype-phenotype relationships to negative symptoms in schizophrenia.Schizophrenia bulletin · 2010Article
- Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4).Molecular and cellular endocrinology · 2010Article
- Dopamine receptor loss of function is not protective of rd1 rod photoreceptors in vivo.Molecular vision · 2009Article
- Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice.Brain research · 2009Article
- Arylbenzazepines are potent modulators for the delayed rectifier K+ channel: a potential mechanism for their neuroprotective effects.PloS one · 2009Article
- Activation of phosphatidylinositol-linked novel D1 dopamine receptor contributes to the calcium mobilization in cultured rat prefrontal cortical astrocytes.Cellular and molecular neurobiology · 2009Article
- Enhanced latent inhibition in dopamine receptor-deficient mice is sex-specific for the D1 but not D2 receptor subtype: implications for antipsychotic drug action.The international journal of neuropsychopharmacology · 2009Article
- Dopamine D2 receptor expression is altered by changes in cellular iron levels in PC12 cells and rat brain tissue.The Journal of nutrition · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMutants with targeted gene deletion ('knockout') or insertion (transgenic) of D1, D2, D3, D4 and D5 dopamine (DA) receptor subtypes are complemented by an increasing variety of double knockout and transgenic-'knockout' models, together with knockout of critical components of DA receptor signalling cascades such as G alpha(olf)[G gamma7], adenylyl cyclase type 5, PKA [RIIbeta] and DARPP-32. However, it is increasingly recognised that these molecular techniques have a number of inherent limitations. Furthermore, there are poorly understood methodological factors that contribute to inconsistent phenotypic findings between laboratories.
objectiveThis review seeks to document the impact of DA receptor subtype and related transduction mutants on our understanding of the behavioural roles of these entities, primarily at the level of unconditioned psychomotor behaviour.
methodsIt includes ethologically based and orofacial movement studies in our own laboratories, since these are the only studies to systematically compare each of the D1, D2, D3, D4 and D5 receptor and DARPP-32 signal transduction 'knockouts'. DISCUSSION: There is a particular emphasis on identifying methodological factors that might influence phenotypic effects and account for inconsistencies. The findings are offered empirically to (1) specify the extent of phenotypic diversity among individual DA receptor subtypes and transduction components and (2) indicate relationships between D1, D2, D3, D4 and D5 receptor subtype proteins, associated G alpha(i)/G alpha(s)/G alpha(olf)[G gamma7]-adenylyl cyclase type 5-PKA [RIIbeta]-DARPP-32 signalling cascades and behaviour. The findings are also offered heuristically as a base for such phenotypic comparisons at additional levels of behaviour so that a yet more complete phenotypic profile might emerge.
Indexed as
Identifiers
16041535What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.