Trial reportPsychopharmacology2005
Modulation of memory and visuospatial processes by biperiden and rivastigmine in elderly healthy subjects.
Trial report in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 71 citations in OpenAlex.
- The antimuscarinic agent biperiden selectively impairs recognition of abstract figures without affecting the processing of non-words.Human psychopharmacology · 2022Trial
- Biperiden Challenge Model in Healthy Elderly as Proof-of-Pharmacology Tool: A Randomized, Placebo-Controlled Trial.Journal of clinical pharmacology · 2021Trial
- Glutamatergic and GABAergic reactivity and cognition in 22q11.2 deletion syndrome and healthy volunteers: A randomized double-blind 7-Tesla pharmacological MRS study.Journal of psychopharmacology (Oxford, England) · 2020Trial
- The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment.Psychopharmacology · 2018Trial
- Effects of biperiden and acute tryptophan depletion and their combination on verbal word memory and EEG.Psychopharmacology · 2017Trial
- Biperiden selectively induces memory impairment in healthy volunteers: no interaction with citalopram.Psychopharmacology · 2015Trial
- A prospective test of the late effects of potentially antineuroplastic drugs in a stroke rehabilitation study.International journal of stroke : official journal of the International Stroke Society · 2014Trial
- Errorless practice as a possible adjuvant to donepezil in Alzheimer's disease.Journal of the International Neuropsychological Society : JINS · 2009Trial
- Acute neuropsychological effects of MDMA and ethanol (co-)administration in healthy volunteers.Psychopharmacology · 2008Trial
- Towards Enhancing Drug Development Methodology to Treat Cognitive Impairment Associated With Schizophrenia and Other Neuropsychiatric Conditions: Insights From 2 Decades of Clinical Trials.Schizophrenia bulletin · 2025Review
- Reducing Visuospatial Pseudoneglect in Healthy Subjects by Active Video Gaming.Brain sciences · 2023Article
- A PAM of the αCurrent research in pharmacology and drug discovery · 2023Article
- Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat.Psychopharmacology · 2018Article
- Anti-Parkinson Drug Biperiden Inhibits Enzyme Acetylcholinesterase.BioMed research international · 2017Article
- A threshold model for opposing actions of acetylcholine on reward behavior: Molecular mechanisms and implications for treatment of substance abuse disorders.Behavioural brain research · 2016Review
- Effects of anticholinergic challenge on psychopathology and cognition in drug-free patients with schizophrenia and healthy volunteers.Psychopharmacology · 2015Article
- Effects of non-pharmacological or pharmacological interventions on cognition and brain plasticity of aging individuals.Frontiers in systems neuroscience · 2014Review
- Dose-dependent effects of ladostigil on microglial activation and cognition in aged rats.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Article
- Cholinergic modulation of auditory processing, sensory gating and novelty detection in human participants.Psychopharmacology · 2013Article
- Performance of conventional pigs and Göttingen miniature pigs in a spatial holeboard task: effects of the putative muscarinic cognition impairer Biperiden.Behavioral and brain functions : BBF · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThe central cholinergic system is implicated in cognitive functioning. The dysfunction of this system is expressed in many diseases like Alzheimer's disease, dementia of Lewy body, Parkinson's disease and vascular dementia. In recent animal studies, it was found that selective cholinergic modulation affects visuospatial processes even more than memory function.
objectiveIn the current study, we tried to replicate those findings. In order to investigate the acute effects of cholinergic drugs on memory and visuospatial functions, a selective anticholinergic drug, biperiden, was compared to a selective acetylcholinesterase-inhibiting drug, rivastigmine, in healthy elderly subjects.
methodsA double-blind, placebo-controlled, randomised, cross-over study was performed in 16 healthy, elderly volunteers (eight men, eight women; mean age 66.1, SD 4.46 years). All subjects received biperiden (2 mg), rivastigmine (3 mg) and placebo with an interval of 7 days between them. Testing took place 1 h after drug intake (which was around Tmax for both drugs). Subjects were presented with tests for episodic memory (wordlist and picture memory), working memory tasks (N-back, symbol recall) and motor learning (maze task, pursuit rotor). Visuospatial abilities were assessed by tests with high visual scanning components (tangled lines and Symbol Digit Substitution Test).
resultsEpisodic memory was impaired by biperiden. Rivastigmine impaired recognition parts of the episodic memory performance. Working memory was non-significantly impaired by biperiden and not affected by rivastigmine. Motor learning as well as visuospatial processes were impaired by biperiden and improved by rivastigmine.
conclusionsThese results implicate acetylcholine as a modulator not only of memory but also of visuospatial abilities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.