ArticleInfection and immunity2005
Mutation of the zinc-binding metalloprotease motif affects Bacteroides fragilis toxin activity but does not affect propeptide processing.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Applying principles of vaccine development to oncomicrobial vaccines.Blood advances · 2025Review
- The Ambivalent Nature ofToxins · 2025Review
- Biological Mechanisms of EnterotoxigenicToxins · 2025Review
- Article
- Review
- The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins.Nature communications · 2021Article
- G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis.Communications biology · 2021Article
- A clostripain-like protease plays a major role in generating the secretome of enterotoxigenic Bacteroides fragilis.Molecular microbiology · 2021Article
- Glucosylceramide production maintains colon integrity in response to Bacteroides fragilis toxin-induced colon epithelial cell signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Dietary Salt Administration Decreases EnterotoxigenicInternational journal of molecular sciences · 2020Article
- Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin.Frontiers in cellular and infection microbiology · 2019Article
- Monoclonal antibodies specific for Bacteroides fragilis enterotoxins BFT1 and BFT2 and their use in immunoassays.PloS one · 2017Article
- Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice.Nature medicine · 2016Article
- Peptide Sequence Region That is Essential for the Interactions of the Enterotoxigenic Bacteroides fragilis Metalloproteinase II with E-cadherin.Journal of proteolysis · 2014Article
- Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes.Clinical microbiology reviews · 2009Review
- Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice.Infection and immunity · 2009Article
- Association of enterotoxigenic Bacteroides fragilis infection with inflammatory diarrhea.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2008Article
- Enterotoxigenic Bacteroides fragilis.Current infectious disease reports · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
To evaluate the role of the zinc-binding metalloprotease in Bacteroides fragilis toxin (BFT) processing and activity, the zinc-binding consensus sequences (H348, E349, H352, G355, H358, and M366) were mutated by site-directed-mutagenesis. Our results indicated that single point mutations in the zinc-binding metalloprotease motif do not affect BFT processing but do reduce or eliminate BFT biologic activity in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.