ArticleInfection and immunity2005
Importance of srtA and srtB for growth of Bacillus anthracis in macrophages.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- The divergent roles of sortase in the biology of Gram-positive bacteria.Cell surface (Amsterdam, Netherlands) · 2021Review
- TheMicroorganisms · 2020Review
- Disparate subcellular location of putative sortase substrates in Clostridium difficile.Scientific reports · 2017Article
- Structure of the Bacillus anthracis Sortase A Enzyme Bound to Its Sorting Signal: A FLEXIBLE AMINO-TERMINAL APPENDAGE MODULATES SUBSTRATE ACCESS.The Journal of biological chemistry · 2015Article
- Morin inhibits sortase A and subsequent biofilm formation in Streptococcus mutans.Current microbiology · 2014Article
- Dual effects of single-walled carbon nanotubes coupled with near-infrared radiation on Bacillus anthracis spores: inactivates spores and stimulates the germination of surviving spores.Journal of biological engineering · 2013Article
- Article
- The Sortase A enzyme that attaches proteins to the cell wall of Bacillus anthracis contains an unusual active site architecture.The Journal of biological chemistry · 2010Article
- Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.Biopolymers · 2010Review
- Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors.Bioorganic & medicinal chemistry · 2009Article
- High-throughput, single-cell analysis of macrophage interactions with fluorescently labeled Bacillus anthracis spores.Applied and environmental microbiology · 2008Article
- Transcriptional profiling of Bacillus anthracis during infection of host macrophages.Infection and immunity · 2007Article
- Surface protein IsdC and Sortase B are required for heme-iron scavenging of Bacillus anthracis.Journal of bacteriology · 2006Article
- Search for Bacillus anthracis potential vaccine candidates by a functional genomic-serologic screen.Infection and immunity · 2006Article
- RrgA and RrgB are components of a multisubunit pilus encoded by the Streptococcus pneumoniae rlrA pathogenicity islet.Infection and immunity · 2006Article
- Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria.Microbiology and molecular biology reviews : MMBR · 2006Review
- Bacillus anthracis IsdG, a heme-degrading monooxygenase.Journal of bacteriology · 2006Article
- Complete sequencing and diversity analysis of the enterotoxin-encoding plasmids in Clostridium perfringens type A non-food-borne human gastrointestinal disease isolates.Journal of bacteriology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the effect of mutation of two sortase genes of Bacillus anthracis, srtA and srtB, on the ability of the bacterium to grow in J774A.1 cells, a mouse macrophage-like cell line. While disruption of either srtA or srtB had no effect on the ability of the bacteria to grow in rich culture media, mutations in each of these genes dramatically attenuated growth of the bacterium in J774A.1 cells. Complementation of the mutation restored the ability of bacteria to grow in the cells. Since the initial events in inhalation anthrax are believed to be uptake of B. anthracis spores by alveolar macrophages followed by germination of the spores and growth of the bacteria within the macrophages, these results suggest that two sortases of B. anthracis may be critical in the early stages of inhalation anthrax.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.