ArticleInfection and immunity2005
Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Biogenically synthesized green silver nanoparticles exhibit antimalarial activity.Discover nano · 2024Article
- Antimalarial and Immunomodulatory Activities ofScientifica · 2024Article
- Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Oxidative Stress in Malaria: Potential Benefits of Antioxidant Therapy.International journal of molecular sciences · 2022Review
- NADPH Oxidase: a Possible Therapeutic Target for Cognitive Impairment in Experimental Cerebral Malaria.Molecular neurobiology · 2022Article
- Article
- Dexamethasone increased the survival rate in Plasmodium berghei-infected mice.Scientific reports · 2021Article
- Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak.PloS one · 2019Article
- Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Myeloperoxidase Attenuates Pathogen Clearance during Plasmodium yoelii Nonlethal Infection.Infection and immunity · 2017Article
- N-acetyl cysteine and mushroom Agaricus sylvaticus supplementation decreased parasitaemia and pulmonary oxidative stress in a mice model of malaria.Malaria journal · 2015Article
- Are reactive oxygen species always detrimental to pathogens?Antioxidants & redox signaling · 2014Review
- Host matrix metalloproteinases in cerebral malaria: new kids on the block against blood-brain barrier integrity?Fluids and barriers of the CNS · 2014Article
- Antioxidant potential of a polyherbal antimalarial as an indicator of its therapeutic value.Advances in pharmacological sciences · 2013Article
- Oxidative stress in malaria.International journal of molecular sciences · 2012Review
- Twofold cost of reproduction: an increase in parental effort leads to higher malarial parasitaemia and to a decrease in resistance to oxidative stress.Proceedings. Biological sciences · 2012Article
- Host resistance to malaria: using mouse models to explore the host response.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy.PLoS pathogens · 2010Article
- Characterization of cerebral malaria in the outbred Swiss Webster mouse infected by Plasmodium berghei ANKA.International journal of experimental pathology · 2009Article
- A central role for free heme in the pathogenesis of severe malaria: the missing link?Journal of molecular medicine (Berlin, Germany) · 2008Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phagocyte-derived reactive oxygen species have been implicated in the clearance of malaria infections. We investigated the progression of five different strains of murine malaria in gp91(phox-/-) mice, which lack a functional NADPH oxidase and thus the ability to produce phagocyte-derived reactive oxygen species. We found that the absence of functional NADPH oxidase in the gene knockout mice had no effect on the parasitemia or total parasite burden in mice infected with either resolving (Plasmodium yoelii and Plasmodium chabaudi K562) or fatal (Plasmodium berghei ANKA, Plasmodium berghei K173 and Plasmodium vinckei vinckei) strains of malaria. This lack of effect was apparent in both primary and secondary infections with P. yoelii and P. chabaudi. There was also no difference in the presentation of clinical or pathological signs between the gp91(phox-/-) or wild-type strains of mice infected with malaria. Progression of P. berghei ANKA and P. berghei K173 infections was unchanged in glutathione peroxidase-1 gene knockout mice compared to their wild-type counterparts. The rates of parasitemia progression in gp91(phox-/-) mice and wild-type mice were not significantly different when they were treated with l-N(G)-methylarginine, an inhibitor of nitric oxide synthase. These results suggest that phagocyte-derived reactive oxygen species are not crucial for the clearance of malaria parasites, at least in murine models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.