ArticleInfection and immunity2005
NK cells help to induce CD8(+)-T-cell immunity against Toxoplasma gondii in the absence of CD4(+) T cells.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 87 citations in OpenAlex.
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- Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.The Journal of experimental medicine · 2021Article
- NK Cells Negatively Regulate CD8 T Cells to Promote Immune Exhaustion and ChronicFrontiers in cellular and infection microbiology · 2020Article
- The IL-12- and IL-23-Dependent NK Cell Response Is Essential for Protective Immunity against SecondaryJournal of immunology (Baltimore, Md. : 1950) · 2019Article
- Bone Marrow NK Cells: Origin, Distinctive Features, and Requirements for Tissue Localization.Frontiers in immunology · 2019Review
- Innate Lymphoid Cells in Protection, Pathology, and Adaptive Immunity During Apicomplexan Infection.Frontiers in immunology · 2019Review
- Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii.Parasites & vectors · 2018Article
- A latent ability to persist: differentiation in Toxoplasma gondii.Cellular and molecular life sciences : CMLS · 2018Review
- Natural killer cells in liver diseases.Frontiers of medicine · 2018Review
- Parasitized Natural Killer cells do not facilitate the spread of Toxoplasma gondii to the brain.Parasite immunology · 2018Article
- The Diverse Role of NK Cells in Immunity to Toxoplasma gondii Infection.PLoS pathogens · 2016Article
- Comparative Analysis of Conventional Natural Killer Cell Responses to Acute Infection withFrontiers in immunology · 2016Article
- Predominant role of interferon-γ in the host protective effect of CD8(+) T cells against Neospora caninum infection.Scientific reports · 2015Article
- CD8+ T cell immunity in an encephalitis model of Toxoplasma gondii infection.Seminars in immunopathology · 2015Review
- MHC Class I Chain-Related Gene A Polymorphisms and Linkage Disequilibrium with HLA-B and HLA-C Alleles in Ocular Toxoplasmosis.PloS one · 2015Article
- Interferon gamma effect on immune mediator production in human nerve cells infected by two strains of Toxoplasma gondii.Parasite (Paris, France) · 2015Article
- Complex immune cell interplay in the gamma interferon response during Toxoplasma gondii infection.Infection and immunity · 2014Review
- Strain-specific properties and T cells regulate the susceptibility to papilloma induction by Mus musculus papillomavirus 1.PLoS pathogens · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
CD8(+) T-cell immunity plays an important role in protection against intracellular infections. Earlier studies have shown that CD4(+) T-cell help was needed for launching in vivo CD8(+) T-cell activity against these pathogens and tumors. However, recently CD4(+) T-cell-independent CD8 responses during several microbial infections including those with Toxoplasma gondii have been described, although the mechanism is not understood. We now demonstrate that, in the absence of CD4(+) T cells, T. gondii-infected mice exhibit an extended NK cell response, which is mediated by continued interleukin-12 (IL-12) secretion. This prolonged NK cell response is critical for priming parasite-specific CD8(+) T-cell immunity. Depletion of NK cells inhibited the generation of CD8(+) T-cell immunity in CD4(-/-) mice. Similarly neutralization of IL-12 reduces NK cell numbers in infected animals and leads to the down-regulation of CD8(+) T-cell immunity against T. gondii. Adoptive transfer of NK cells into the IL-12-depleted animals restored their CD8(+) T-cell immune response, and animals exhibited reduced mortality. NK cell gamma interferon was essential for cytotoxic T-lymphocyte priming. Our studies for the first time demonstrate that, in the absence of CD4(+) T cells, NK cells can play an important role in induction of primary CD8(+) T-cell immunity against an intracellular infection. These observations have therapeutic implications for immunocompromised individuals, including those with human immunodeficiency virus infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.