ArticleInfection and immunity2005
Global gene expression and the role of sigma factors in Neisseria gonorrhoeae in interactions with epithelial cells.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Host-pathogen interaction: Enterobacter cloacae exerts different adhesion and invasion capacities against different host cell types.PloS one · 2023Article
- Bacterial Stress Responses as Potential Targets in Overcoming Antibiotic Resistance.Microorganisms · 2022Review
- Adherence Enables Neisseria gonorrhoeae to Overcome Zinc Limitation Imposed by Nutritional Immunity Proteins.Infection and immunity · 2022Article
- Inorganic nanohybrids combat antibiotic-resistant bacteria hiding within human macrophages.Nanoscale · 2021Article
- Expansion and Functional Diversification of TFIIB-Like Factors in Plants.International journal of molecular sciences · 2021Review
- The Alternative Sigma Factor RpoE2 Is Involved in the Stress Response to Hypochlorite andFrontiers in microbiology · 2021Article
- Contribution of σJournal of bacteriology · 2019Article
- Sequence Determinants Spanning -10 Motif and Spacer Region Implicated in UniqueFrontiers in microbiology · 2019Article
- Substantial Contribution of SmeDEF, SmeVWX, SmQnr, and Heat Shock Response to Fluoroquinolone Resistance in Clinical Isolates ofFrontiers in microbiology · 2019Article
- Evaluation of CpxRA as a Therapeutic Target for Uropathogenic Escherichia coli Infections.Infection and immunity · 2018Article
- The NarE protein of Neisseria gonorrhoeae catalyzes ADP-ribosylation of several ADP-ribose acceptors despite an N-terminal deletion.FEMS microbiology letters · 2016Article
- Identification of an outer membrane lipoprotein involved in nasopharyngeal colonization by Moraxella catarrhalis in an animal model.Infection and immunity · 2014Article
- Transcriptional landscape and essential genes of Neisseria gonorrhoeae.Nucleic acids research · 2014Article
- The σE pathway is involved in biofilm formation by Crohn's disease-associated adherent-invasive Escherichia coli.Journal of bacteriology · 2013Article
- Burkholderia pseudomallei transcriptional adaptation in macrophages.BMC genomics · 2012Article
- Increased expression of the type IV secretion system in piliated Neisseria gonorrhoeae variants.Journal of bacteriology · 2010Article
- Molecular mechanisms of ethanol-induced pathogenesis revealed by RNA-sequencing.PLoS pathogens · 2010Article
- The dawning era of comprehensive transcriptome analysis in cellular microbiology.Frontiers in microbiology · 2010Article
- MtrR modulates rpoH expression and levels of antimicrobial resistance in Neisseria gonorrhoeae.Journal of bacteriology · 2009Article
- Inhibition of Neisseria gonorrhoeae epithelial cell interactions by vaginal Lactobacillus species.Infection and immunity · 2008Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Like many bacterial pathogens, Neisseria gonorrhoeae must adapt to environmental changes in order to successfully colonize and proliferate in a new host. Modulation of gene expression in response to environmental signals is an efficient mechanism used by bacteria to achieve this goal. Using DNA microarrays and a tissue culture model for gonococcal infection, we examined global changes in gene expression in N. gonorrhoeae in response to adherence to host cells. Among those genes induced upon adherence to human epithelial cells in culture was rpoH, which encodes a homolog of the heat shock sigma factor, sigma(32) (RpoH), as well as genes of the RpoH regulon, groEL and groES. Attempts to construct an rpoH null mutant in N. gonorrhoeae were unsuccessful, suggesting that RpoH is essential for viability of N. gonorrhoeae. The extracytoplasmic sigma factor, RpoE (sigma(E)), while known to regulate rpoH in other bacteria, was found not to be necessary for the up-regulation of rpoH in gonococci upon adherence to host cells. To examine the role of RpoH in host cell interactions, an N. gonorrhoeae strain conditionally expressing rpoH was constructed. The results of our experiments showed that while induction of rpoH expression is not necessary for adherence of gonococci to epithelial cells, it is important for the subsequent invasion step, as gonococci depleted for rpoH invade cells two- to threefold less efficiently than a wild-type strain. Taken together, these results indicate that sigma(32), but not sigma(E), is important for the response of gonococci in the initial steps of an infection.
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