ArticleInfection and immunity2005
Identification and characterization of the locus for diffuse adherence, which encodes a novel afimbrial adhesin found in atypical enteropathogenic Escherichia coli.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- EPEC autotransporter adhesin (Eaa): a novel adhesin identified in atypical enteropathogenicFrontiers in cellular and infection microbiology · 2025Article
- Phylogenetic relationship and virulence composition ofFrontiers in microbiology · 2023Article
- Quantitative analysis and virulence phenotypes of atypical enteropathogenicGut microbes · 2020Article
- Large plasmids encoding antibiotic resistance and localized-like adherence in atypical enteropathogenic Escherichia coli strains.BMC microbiology · 2020Article
- Recent Advances in Genetic Tools forFrontiers in genetics · 2020Review
- Induction of the immunoprotective coat of Yersinia pestis at body temperature is mediated by the Caf1R transcription factor.BMC microbiology · 2019Article
- Pili Assembled by the Chaperone/Usher Pathway inEcoSal Plus · 2018Review
- The Mobilome; A Major Contributor toFrontiers in microbiology · 2017Article
- Diarrheagenic Escherichia coli.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2016Review
- Article
- Molecular and phenotypic characterization of Escherichia coli O26:H8 among diarrheagenic E. coli O26 strains isolated in Brazil.Applied and environmental microbiology · 2013Article
- Dissection of the role of pili and type 2 and 3 secretion systems in adherence and biofilm formation of an atypical enteropathogenic Escherichia coli strain.Infection and immunity · 2013Article
- RegR virulence regulon of rabbit-specific enteropathogenic Escherichia coli strain E22.Infection and immunity · 2013Article
- Identification of Coli Surface Antigen 23, a novel adhesin of enterotoxigenic Escherichia coli.Infection and immunity · 2012Article
- Adherence of Escherichia coli O157:H7 to epithelial cells in vitro and in pig gut loops is affected by bacterial culture conditions.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2011Article
- Adherence factors in atypical enteropathogenic Escherichia coli strains expressing the localized adherence-like pattern in HEp-2 cells.Journal of clinical microbiology · 2010Article
- Evidence of pathogenic subgroups among atypical enteropathogenic Escherichia coli strains.Journal of clinical microbiology · 2009Article
- Putative adhesins of enteropathogenic and enterohemorrhagic Escherichia coli of serogroup O26 isolated from humans and cattle.Journal of clinical microbiology · 2009Article
- Characterisation of atypical enteropathogenic E. coli strains of clinical origin.BMC microbiology · 2009Article
- Contribution of the pst-phoU operon to cell adherence by atypical enteropathogenic Escherichia coli and virulence of Citrobacter rodentium.Infection and immunity · 2009Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The O26 serogroup of enteropathogenic Escherichia coli (EPEC) is one of the serogroups most frequently implicated in infant diarrhea and is also common among enterohemorrhagic E. coli (EHEC) strains. The most common O26 strains belong to EPEC/EHEC serotype O26:H11 and are generally Shiga toxin (Stx) positive. Stx-negative E. coli strains that are negative for the EPEC EAF plasmid and bundle-forming pilus (Bfp) are classified as atypical EPEC. Here, we report a novel adhesin present in an stx-negative bfpA-negative atypical EPEC O26:H11 strain isolated from an infant with diarrhea. A cloned 15-kb genomic region from this strain, designated the locus for diffuse adherence (lda), confers diffuse adherence on HEp-2 cells when expressed in E. coli K-12. Sequence analysis of lda revealed a G+C content of 46.8% and 15 open reading frames sharing homology with the E. coli K88 fae and CS31A clp fimbrial operons. The lda region is part of a putative 26-kb genomic island inserted into the proP gene of the E. coli chromosome. Hybridization studies have demonstrated the prevalence of the minor structural subunit gene, ldaH, across E. coli serogroups O5, O26, O111, and O145. A second plasmid-encoded factor that contributed to the Hep-2 adherence of this strain was also identified but was not characterized. Null mutations that abolish adherence to HEp-2 cells can be restored by plasmid complementation. Antiserum raised against the major structural subunit, LdaG, recognizes a 25-kDa protein from crude heat-extracted protein preparations and inhibits the adherence of the E. coli DH5alpha lda(+) clone to HEp-2 cells. Electron microscopy revealed a nonfimbrial structure surrounding the bacterial cell.
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