ArticleInfection and immunity2005
Influence of Na(+), dicarboxylic amino acids, and pH in modulating the low-calcium response of Yersinia pestis.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- The gatekeeper of Yersinia type III secretion is under RNA thermometer control.PLoS pathogens · 2021Article
- Life After Secretion-Frontiers in microbiology · 2019Article
- Type III secretion systems: the bacterial flagellum and the injectisome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Na+/H+ antiport is essential for Yersinia pestis virulence.Infection and immunity · 2013Article
- RfaL is required for Yersinia pestis type III secretion and virulence.Infection and immunity · 2013Article
- A multi-omic systems approach to elucidating Yersinia virulence mechanisms.Molecular bioSystems · 2013Article
- Article
- Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cells.PloS one · 2012Article
- An experimentally-supported genome-scale metabolic network reconstruction for Yersinia pestis CO92.BMC systems biology · 2011Article
- Global gene expression profiling of Yersinia pestis replicating inside macrophages reveals the roles of a putative stress-induced operon in regulating type III secretion and intracellular cell division.Infection and immunity · 2010Article
- YopD self-assembly and binding to LcrV facilitate type III secretion activity by Yersinia pseudotuberculosis.The Journal of biological chemistry · 2010Article
- The importance of the small RNA chaperone Hfq for growth of epidemic Yersinia pestis, but not Yersinia pseudotuberculosis, with implications for plague biology.Journal of bacteriology · 2010Article
- Evaluation of a Yersinia pestis mutant impaired in a thermoregulated type VI-like secretion system in flea, macrophage and murine models.Microbial pathogenesis · 2009Article
- Growth of calcium-blind mutants of Yersinia pestis at 37 degrees C in permissive Ca2+-deficient environments.Microbiology (Reading, England) · 2009Article
- Molecular Darwinian evolution of virulence in Yersinia pestis.Infection and immunity · 2009Review
- Cross-talk between type three secretion system and metabolism in Yersinia.The Journal of biological chemistry · 2009Article
- Induction of the Yersinia type 3 secretion system as an all-or-none phenomenon.Journal of molecular biology · 2007Article
- A surface-focused biotinylation procedure identifies the Yersinia pestis catalase KatY as a membrane-associated but non-surface-located protein.Applied and environmental microbiology · 2007Article
- Recent findings regarding maintenance of enzootic variants of Yersinia pestis in sylvatic reservoirs and their significance in the evolution of epidemic plague.Vector borne and zoonotic diseases (Larchmont, N.Y.)Article
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1 author at 1 institution in 1 country.
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Abstract
The virulence of yersiniae is promoted in part by shared approximately 70-kb plasmids (pCD in Yersinia pestis and pYV in enteropathogenic Yersinia pseudotuberculosis and Yersinia enterocolitica) that mediate a low-calcium response. This phenotype is characterized at 37 degrees C by either bacteriostasis in Ca(2+)-deficient medium with expression of pCD/pYV-encoded virulence effectors (Yops and LcrV) or vegetative growth and repression of Yops and LcrV with > or =2.5 mM Ca(2+) (Lcr(+)). Regulation of Yops and LcrV is well defined but little is known about bacteriostasis other than that Na(+) plus l-glutamate promotes prompt restriction of Y. pestis. As shown here, l-aspartate substituted for l-glutamate in this context but only Na(+) exacerbated the nutritional requirement for Ca(2+). Bacteriostasis of Y. pestis (but not enteropathogenic yersiniae) was abrupt in Ca(2+)-deficient medium at neutral to slightly alkaline pH (7.0 to 8.0), although increasing the pH to 8.5 or 9.0, especially with added Na(+) (but not l-glutamate), facilitated full-scale growth. Added l-glutamate (but not Na(+)) favored Ca(2+)-independent growth at acidic pH (5.0 to 6.5). Yops and LcrV were produced in Ca(2+)-deficient media at pH 6.5 to 9.0 regardless of the presence of added Na(+) or l-glutamate, although their expression at alkaline pH was minimal. Resting Ca(2+)-starved Lcr(+) cells of Y. pestis supplied with l-glutamate first excreted and then destroyed l-aspartate. These findings indicate that expression of Yops and LcrV is necessary but not sufficient for bacteriostasis of Ca(2+)-starved yersiniae and suggest that abrupt restriction of Y. pestis requires Na(+) and the known absence of aspartate ammonia-lyase in this species.
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