ArticleInfection and immunity2005
Exposure to rumen protozoa leads to enhancement of pathogenicity of and invasion by multiple-antibiotic-resistant Salmonella enterica bearing SGI1.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 78 citations in OpenAlex.
- Article
- Making a Pathogen? Evaluating the Impact of Protist Predation on the Evolution of Virulence in Serratia marcescens.Genome biology and evolution · 2024Article
- Protistan predation selects for antibiotic resistance in soil bacterial communities.The ISME journal · 2023Article
- Adaptation to an Amoeba Host Leads to Pseudomonas aeruginosa Isolates with Attenuated Virulence.Applied and environmental microbiology · 2022Article
- Adaptation to an amoeba host drives selection of virulence-associated traits in Vibrio cholerae.The ISME journal · 2022Article
- Epidemiology, Serotype and Resistance ofInfection and drug resistance · 2022Article
- Microbial warfare in the wild-the impact of protists on the evolution and virulence of bacterial pathogens.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Review
- Targeting the Hindgut to Improve Health and Performance in Cattle.Animals : an open access journal from MDPI · 2020Review
- The Impact of Protozoan Predation on the Pathogenicity ofFrontiers in microbiology · 2020Review
- Fecal microbiota transplantation as a tool to treat and reduce susceptibility to disease in animals.Veterinary immunology and immunopathology · 2018Review
- β-Defensins: Farming the Microbiome for Homeostasis and Health.Frontiers in immunology · 2018Review
- "Does the Salmonella Genomic Island 1 (SGI1) confer invasiveness properties to human isolates?"BMC infectious diseases · 2017Article
- Free-Living Amoebae as Hosts for and Vectors of Intracellular Microorganisms with Public Health Significance.Viruses · 2017Review
- Identification ofFrontiers in cellular and infection microbiology · 2016Article
- The Role of Ciliate Protozoa in the Rumen.Frontiers in microbiology · 2015Review
- Phages can constrain protist predation-driven attenuation of Pseudomonas aeruginosa virulence in multienemy communities.The ISME journal · 2014Article
- Rapid detection of predation of Escherichia coli O157:H7 and sorting of bacterivorous Tetrahymena by flow cytometry.Frontiers in cellular and infection microbiology · 2014Article
- Strain differences in fitness of Escherichia coli O157:H7 to resist protozoan predation and survival in soil.PloS one · 2014Article
- Tetracycline accelerates the temporally-regulated invasion response in specific isolates of multidrug-resistant Salmonella enterica serovar Typhimurium.BMC microbiology · 2013Article
- Initial symbiont contact orchestrates host-organ-wide transcriptional changes that prime tissue colonization.Cell host & microbe · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple-antibiotic-resistant Salmonella enterica serotype Typhimurium is a food-borne pathogen that has been purported to be more virulent than antibiotic-sensitive counterparts. The paradigm for this multiresistant/hyperpathogenic phenotype is Salmonella enterica serotype Typhimurium phage type DT104 (DT104). The basis for the multiresistance in DT104 is related to an integron structure designated SGI1, but factors underlying hyperpathogenicity have not been completely identified. Since protozoa have been implicated in the alteration of virulence in Legionella and Mycobacterium spp., we attempted to assess the possibility that protozoa may contribute to the putative hypervirulence of DT104. Our study reveals that DT104 can be more invasive, as determined by a tissue culture invasion assay, after surviving within protozoa originating from the bovine rumen. The enhancement of invasion was correlated with hypervirulence in a bovine infection model in which we observed a more rapid progression of disease and a greater recovery rate for the pathogen. Fewer DT104 cells were recovered from tissues of infected animals when protozoa were lysed by preinfection chemical defaunation of the bovine or ovine rumen. The protozoan-mediated hypervirulence phenotype was observed only in DT104 and other Salmonella strains, including serovars Agona and Infantis, possessing SGI1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.