ArticleInfection and immunity2005
Analysis of cell type-specific responses mediated by the type IV secretion system of Helicobacter pylori.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comprehensive Integration of Genome-Wide Association and Gene Expression Studies Reveals Novel Gene Signatures and Potential Therapeutic Targets forFrontiers in immunology · 2021Pooled it
- Genetic variation in the cag pathogenicity island of Helicobacter pylori strains detected from gastroduodenal patients in Thailand.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Different roles of integrin-β1 and integrin-αv for type IV secretion of CagA versus cell elongation phenotype and cell lifting by Helicobacter pylori.PLoS pathogens · 2020Article
- Type IV secretion ofGut pathogens · 2020Article
- Type IV Secretion and Signal Transduction of Helicobacter pylori CagA through Interactions with Host Cell Receptors.Toxins · 2017Review
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- In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.Gastroenterology · 2015Article
- Helicobacter pylori outer membrane protein HopQ identified as a novel T4SS-associated virulence factor.Cellular microbiology · 2013Article
- Regulation of the actin cytoskeleton in Helicobacter pylori-induced migration and invasive growth of gastric epithelial cells.Cell communication and signaling : CCS · 2011Article
- Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori.Cell communication and signaling : CCS · 2011Article
- Complex cellular responses of Helicobacter pylori-colonized gastric adenocarcinoma cells.Infection and immunity · 2011Article
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- High-throughput and single-cell imaging of NF-kappaB oscillations using monoclonal cell lines.BMC cell biology · 2010Article
- Helicobacter pylori: bacterial factors and the role of cytokines in the immune response.Current microbiology · 2010Article
- Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner.PLoS pathogens · 2009Article
- NF-kappaB activation during acute Helicobacter pylori infection in mice.Infection and immunity · 2008Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori persistently infects the human stomach and can cause gastritis, gastric ulceration, and gastric cancer. The type IV secretion system (TFSS) of virulent H. pylori strains translocates the CagA protein, inducing the dephosphorylation of host cell proteins and leading to changes in the morphology or shape of AGS gastric epithelial cells. Furthermore, the TFSS is involved in the induction of proinflammatory cytokines. While the H. pylori genes required for TFSS function have been investigated systematically, little is known about possible host cell factors involved. We infected 19 different mammalian cell lines individually with H. pylori and analyzed CagA translocation, dephosphorylation of host cell proteins, chemokine secretion (interleukin-8 and macrophage inflammatory protein 2), and changes in cellular phenotypes. Our results demonstrate that not only bacterial but also host cell factors determine the cellular response to infection. The identification of such unknown host cell factors will add to our understanding of host-pathogen interactions and might help in the development of new therapeutic strategies.
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