ArticleInfection and immunity2005
Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 91 citations in OpenAlex.
- Article
- Article
- An array of signal-specific MoYpd1 isoforms determines full virulence in the pathogenic fungus Magnaporthe oryzae.Communications biology · 2024Article
- Impact of Lysine Succinylation on the Biology of Fungi.Current issues in molecular biology · 2024Review
- Article
- Role of Protein Glycosylation in Interactions of Medically Relevant Fungi with the Host.Journal of fungi (Basel, Switzerland) · 2021Review
- The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020Review
- N-glycosylation of the protein disulfide isomerase Pdi1 ensures full Ustilago maydis virulence.PLoS pathogens · 2019Article
- Divergent Approaches to Virulence inInternational journal of molecular sciences · 2019Review
- In Vitro Antifungal and Antivirulence Activities of Biologically Synthesized Ethanolic Extract of Propolis-Loaded PLGA Nanoparticles againstEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Identification of an Exceptionally Long Intron in themSphere · 2018Article
- Protein O-mannosyltransferases are required for sterigmatocystin production and developmental processes in Aspergillus nidulans.Current genetics · 2018Article
- Mannan Molecular Substructures Control Nanoscale Glucan Exposure in Candida.Cell reports · 2018Article
- Evolutionarily Conserved and Divergent Roles of Unfolded Protein Response (UPR) in the Pathogenic Cryptococcus Species Complex.Scientific reports · 2018Article
- The first succinylome profile of Trichophyton rubrum reveals lysine succinylation on proteins involved in various key cellular processes.BMC genomics · 2017Article
- Dom34 Links Translation to Protein O-mannosylation.PLoS genetics · 2016Article
- β-1,2-Mannosyltransferases 1 and 3 Participate in Yeast and Hyphae O- and N-Linked Mannosylation and Alter Candida albicans Fitness During Infection.Open forum infectious diseases · 2015Article
- Dressed to impress: impact of environmental adaptation on the Candida albicans cell wall.Molecular microbiology · 2015Review
- Candida albicans phospholipomannan: a sweet spot for controlling host response/inflammation.Seminars in immunopathology · 2015Review
- Cigarette smoke condensate increases C. albicans adhesion, growth, biofilm formation, and EAP1, HWP1 and SAP2 gene expression.BMC microbiology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The PMT gene family in Candida albicans encodes five isoforms of protein mannosyltransferases (Pmt proteins Pmt1p, Pmt2p, Pmt4p, Pmt5p, and Pmt6p) that initiate O mannosylation of secretory proteins. We compared virulence characteristics of pmt mutants in two complex, three-dimensional models of localized candidiasis, using reconstituted human epithelium (RHE) and engineered human oral mucosa (EHOM); in addition, mutants were tested in a mouse model of hematogenously disseminated candidiasis (HDC). All pmt mutants showed attenuated virulence in the HDC model and at least one model of localized candidiasis. The pmt5 mutant, which lacks in vitro growth phenotypes, was less virulent in the EHOM and HDC assays but had no consistent phenotype in the RHE assay. In contrast, the pmt4 and pmt6 mutants were less virulent in the RHE and HDC assays but not in the EHOM assay. The results stress the contribution of all Pmt isoforms to the virulence of C. albicans and suggest that the importance of individual Pmt isoforms may differ in specific host niches. We propose that Pmt proteins may be suitable targets for future novel classes of antifungal agents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.