ArticleInfection and immunity2005
Degradation of Chlamydia pneumoniae by peripheral blood monocytic cells.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Opsonophagocytosis of Chlamydia pneumoniae by Human Monocytes and Neutrophils.Infection and immunity · 2020Article
- Alternatively Activated Macrophages Are Host Cells forFrontiers in microbiology · 2019Article
- M2 Polarization of Human Macrophages Favors Survival of the Intracellular Pathogen Chlamydia pneumoniae.PloS one · 2015Article
- Human blood monocytes support persistence, but not replication of the intracellular pathogen C. pneumoniae.BMC immunology · 2014Article
- Differential infection outcome of Chlamydia trachomatis in human blood monocytes and monocyte-derived dendritic cells.BMC microbiology · 2014Article
- Glycosylphosphatidylinositol anchoring directs the assembly of Sup35NM protein into non-fibrillar, membrane-bound aggregates.The Journal of biological chemistry · 2014Article
- Infection of human monocytes by Chlamydia pneumoniae and Chlamydia trachomatis: an in vitro comparative study.BMC research notes · 2014Article
- Perforin-2 restricts growth of Chlamydia trachomatis in macrophages.Infection and immunity · 2013Article
- Chlamydia pneumoniae impairs the innate immune response in infected epithelial cells by targeting TRAF3.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The sst1 resistance locus regulates evasion of type I interferon signaling by Chlamydia pneumoniae as a disease tolerance mechanism.PLoS pathogens · 2013Article
- Regulation of chlamydial infection by host autophagy and vacuolar ATPase-bearing organelles.Infection and immunity · 2011Article
- Is C. Pneumoniae research in peril?Frontiers in microbiology · 2011Article
- Chlamydia pneumoniae hides inside apoptotic neutrophils to silently infect and propagate in macrophages.PloS one · 2009Article
- Amalgamation of Chlamydia pneumoniae inclusions with lipid droplets in foam cells in human atherosclerotic plaque.Virchows Archiv : an international journal of pathology · 2008Article
- Survival of Chlamydia muridarum within dendritic cells.Infection and immunity · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Chlamydia pneumoniae is a common human respiratory pathogen that has been associated with a variety of chronic diseases, including atherosclerosis. The role of this organism in the pathogenesis of atherosclerosis remains unknown. A key question is how C. pneumoniae is transferred from the site of primary infection to a developing atherosclerotic plaque. It has been suggested that circulating monocytes could be vehicles for dissemination of C. pneumoniae since the organism has been detected in peripheral blood monocytic cells (PBMCs). In this study we focused on survival of C. pneumoniae within PBMCs isolated from the blood of healthy human donors. We found that C. pneumoniae does not grow and multiply in cultured primary monocytes. In C. pneumoniae-infected monocyte-derived macrophages, growth of the organism was very limited, and the majority of the bacteria were eradicated. We also found that the destruction of C. pneumoniae within infected macrophages resulted in a gradual diminution of chlamydial antigens, although some of these antigens could be detected for days after the initial infection. The detected antigens present in infected monocytes and monocyte-derived macrophages represented neither chlamydial inclusions nor intact organisms. The use of {N-[7-(4-nitrobenzo-2-oxa-1,3-diazole)]}-6-aminocaproyl-d-erythro-sphingosine as a vital stain for chlamydiae proved to be a sensitive method for identifying rare C. pneumoniae inclusions and was useful in the detection of even aberrant developmental forms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.