ArticleInfection and immunity2005
TcpF is a soluble colonization factor and protective antigen secreted by El Tor and classical O1 and O139 Vibrio cholerae serogroups.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- Allelic variations and gene cluster modularity act as nonlinear bottlenecks for cholera emergence.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae.Cell · 2023Article
- Mechanism of secretion of TcpF by theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Structural basis for the toxin-coregulated pilus-dependent secretion ofScience advances · 2022Article
- Production of putative enhanced oral cholera vaccine strains that express toxin-coregulated pilus.PloS one · 2017Article
- The Vibrio cholerae Minor Pilin TcpB Initiates Assembly and Retraction of the Toxin-Coregulated Pilus.PLoS pathogens · 2016Article
- Crystal Structure of the Minor Pilin CofB, the Initiator of CFA/III Pilus Assembly in Enterotoxigenic Escherichia coli.The Journal of biological chemistry · 2015Article
- Secretion of TcpF by the Vibrio cholerae toxin-coregulated pilus biogenesis apparatus requires an N-terminal determinant.Journal of bacteriology · 2013Article
- Article
- Nutrient-dependent, rapid transition of Vibrio cholerae to coccoid morphology and expression of the toxin co-regulated pilus in this form.Microbiology (Reading, England) · 2011Article
- Protection and attachment of Vibrio cholerae mediated by the toxin-coregulated pilus in the infant mouse model.Journal of bacteriology · 2011Article
- A genome-wide approach to discovery of small RNAs involved in regulation of virulence in Vibrio cholerae.PLoS pathogens · 2011Article
- Crystal structure of the Vibrio cholerae colonization factor TcpF and identification of a functional immunogenic site.Journal of molecular biology · 2011Article
- H-NS binding and repression of the ctx promoter in Vibrio cholerae.Journal of bacteriology · 2011Article
- Vibrio cholerae: lessons for mucosal vaccine design.Expert review of vaccines · 2011Review
- A bistable switch and anatomical site control Vibrio cholerae virulence gene expression in the intestine.PLoS pathogens · 2010Article
- Role of FlgT in anchoring the flagellum of Vibrio cholerae.Journal of bacteriology · 2010Article
- Characterization of two outer membrane proteins, FlgO and FlgP, that influence vibrio cholerae motility.Journal of bacteriology · 2009Article
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2 authors.
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Abstract
Vibrio cholerae causes diarrhea by colonizing the human small bowel and intoxicating epithelial cells. Colonization is a required step in pathogenesis, and strains defective for colonization are significantly attenuated. The best-characterized V. cholerae colonization factor is the toxin-coregulated pilus (TCP). It has been demonstrated that TCP is required for V. cholerae colonization in both humans and mice. TCP enhances bacterial interactions that allow microcolony formation and thereby promotes survival in the intestine. We have recently discovered that the TCP biogenesis apparatus also serves as a secretion system, mediating the terminal step in the extracellular secretion pathway of TcpF. TcpF was identified in classical isolates of V. cholerae O1 as a soluble factor essential for colonization in the infant mouse cholera model. In the present study, we expanded our analysis of TcpF to include the O1 El Tor and O139 serogroups and investigated how TCP and TcpF act together to mediate colonization. Additionally, we demonstrated that antibodies generated against TcpF are protective against experimental V. cholerae infection in the infant mouse cholera model. This observation, coupled with the fact that TcpF is a potent mediator of colonization, suggests that TcpF should be considered as a component of a polyvalent cholera vaccine formulation.
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