ArticleProceedings of the National Academy of Sciences of the United States of America2005
Expression, physiological action, and coexpression patterns of neuropeptide Y in rat taste-bud cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 106 citations in OpenAlex.
- Neuropeptide Y and peptide YY differentially modulate bitter- and fatty acid-evoked responses in human fungiform taste bud cells.American journal of physiology. Cell physiology · 2026Article
- Potential role of glucagon like peptide 1 in taste receptors.Frontiers in endocrinology · 2025Review
- Endocrinology of Taste with Aging.Endocrinology and metabolism clinics of North America · 2023Review
- Sweet Taste Signaling: The Core Pathways and Regulatory Mechanisms.International journal of molecular sciences · 2022Review
- Y1 receptors modulate taste-related behavioral responsiveness in male mice to prototypical gustatory stimuli.Hormones and behavior · 2021Article
- Do Gut Microbes Taste?Nutrients · 2021Review
- Recent Advances in Understanding Peripheral Taste Decoding I: 2010 to 2020.Endocrinology and metabolism (Seoul, Korea) · 2021Review
- Recent Advances in Neural Circuits for Taste Perception in Hunger.Frontiers in neural circuits · 2021Review
- An alternative pathway for sweet sensation: possible mechanisms and physiological relevance.Pflugers Archiv : European journal of physiology · 2020Review
- Consequences of Obesity on the Sense of Taste: Taste Buds as Treatment Targets?Diabetes & metabolism journal · 2020Review
- Taste Receptor Cells in Mice Express Receptors for the Hormone Adiponectin.Chemical senses · 2019Article
- The Role of Cholecystokinin in Peripheral Taste Signaling in Mice.Frontiers in physiology · 2017Article
- Proceedings of the 2015 ASPEN Research Workshop-Taste Signaling.JPEN. Journal of parenteral and enteral nutrition · 2017Article
- Glucagon-like peptide-1 is specifically involved in sweet taste transmission.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- The endocrinology of taste receptors.Nature reviews. Endocrinology · 2015Review
- Molecular mechanisms of taste recognition: considerations about the role of saliva.International journal of molecular sciences · 2015Review
- Taste perception, associated hormonal modulation, and nutrient intake.Nutrition reviews · 2015Review
- L-Amino Acids Elicit Diverse Response Patterns in Taste Sensory Cells: A Role for Multiple Receptors.PloS one · 2015Article
- Interleukin-10 is produced by a specific subset of taste receptor cells and critical for maintaining structural integrity of mouse taste buds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Ingestion of bacterial lipopolysaccharide inhibits peripheral taste responses to sucrose in mice.Neuroscience · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Recent studies have suggested that neuropeptides could play previously unrecognized functional roles in peripheral gustation. To date, two peptides, cholecystokinin and vasoactive intestinal peptide, have been localized to subsets of taste-bud (TB) cells (TBC) and one, cholecystokinin, has been demonstrated to produce excitatory physiological actions. This study extends our knowledge of neuropeptides in TBC in three significant ways. First, using techniques of immunocytochemistry and RT-PCR, evidence is presented for the expression of a third peptide, neuropeptide Y (NPY). Like other peptide expression patterns, NPY expression is circumscribed to a subset of cells within the taste bud. Second, using physiological studies, we demonstrate that NPY specifically enhances an inwardly rectifying potassium current via NPY-Y1 receptors. This action is antagonistic to the previously demonstrated inhibitory effect exerted by cholecystokinin on the same current, thus providing important clues to their signaling roles in the TB. Third, using the technique of double-labeled fluorescent immunocytochemistry, the relationship of three subsets of neuropeptide-expressing TB cells to one another was examined. Remarkably, NPY expressions, although fewer in number than either the cholecystokinin or vasoactive intestinal peptide subsets, overlapped 100% with either peptide. Collectively, these three observations transform previously suggestive roles of neuromodulation by peptides in TB cells to more concrete signaling pathways. The extensive colocalization of these peptides suggests they may be subject to similar presynaptic influences of release yet have antagonistic postsynaptic actions. The convergence or divergence of these postsynaptic actions awaits further investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.