ArticleBiophysical journal2006
Role of voltage-dependent modulation of store Ca2+ release in synchronization of Ca2+ oscillations.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 81 citations in OpenAlex.
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- Vasorelaxant effect of sinensetin via the NO/sGC/cGMP pathway and potassium and calcium channels.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Phase waves and trigger waves: emergent properties of oscillating and excitable networks in the gut.The Journal of physiology · 2018Review
- Spatial Noise in Coupling Strength and Natural Frequency within a Pacemaker Network; Consequences for Development of Intestinal Motor Patterns According to a Weakly Coupled Phase Oscillator Model.Frontiers in neuroscience · 2016Article
- Effects of gap junction inhibition on contraction waves in the murine small intestine in relation to coupled oscillator theory.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeat.Frontiers in physiology · 2015Review
- Expression and function of a T-type Ca2+ conductance in interstitial cells of Cajal of the murine small intestine.American journal of physiology. Cell physiology · 2014Article
- Mechanism of vasorelaxation induced by Achillea wilhelmsii in rat isolated thoracic aorta.Advanced biomedical research · 2014Article
- Endothelium-independent vasorelaxant effects of hydroalcoholic extract from Nigella sativa seed in rat aorta: the roles of Ca2+ and K+ channels.BioMed research international · 2014Article
- Notch4-dependent antagonism of canonical TGF-β1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells.American journal of physiology. Renal physiology · 2013Article
- Spatial analysis of slowly oscillating electric activity in the gut of mice using low impedance arrayed microelectrodes.PloS one · 2013Article
- Pregnancy enhances sustained Ca2+ bursts and endothelial nitric oxide synthase activation in ovine uterine artery endothelial cells through increased connexin 43 function.Biology of reproduction · 2010Article
- Biophysically based mathematical modeling of interstitial cells of Cajal slow wave activity generated from a discrete unitary potential basis.Biophysical journal · 2009Article
- Smooth muscle cell calcium activation mechanisms.The Journal of physiology · 2008Review
- A biophysically based mathematical model of unitary potential activity in interstitial cells of Cajal.Biophysical journal · 2008Article
- Tone-dependent vascular responses to astrocyte-derived signals.American journal of physiology. Heart and circulatory physiology · 2008Article
- Pacemaking through Ca2+ stores interacting as coupled oscillators via membrane depolarization.Biophysical journal · 2007Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Slow waves are rhythmic depolarizations that underlie mechanical activity of many smooth muscles. Slow waves result through rhythmic Ca(2+) release from intracellular Ca(2+) stores through inositol 1,4,5-trisphosphate (IP(3)) sensitive receptors and Ca(2+)-induced Ca(2+) release. Ca(2+) oscillations are transformed into membrane depolarizations by generation of a Ca(2+)-activated inward current. Importantly, the store Ca(2+) oscillations that underlie slow waves are entrained across many cells over large distances. It has been shown that IP(3) receptor-mediated Ca(2+) release is enhanced by membrane depolarization. Previous studies have implicated diffusion of Ca(2+) or the second messenger IP(3) across gap junctions in synchronization of Ca(2+) oscillations. In this study, a novel mechanism of Ca(2+) store entrainment through depolarization-induced IP(3) receptor-mediated Ca(2+) release is investigated. This mechanism is significantly different from chemical coupling-based mechanisms, as membrane potential has a coupling effect over distances several orders of magnitude greater than either diffusion of Ca(2+) or IP(3) through gap junctions. It is shown that electrical coupling acting through voltage-dependent modulation of store Ca(2+) release is able to synchronize oscillations of cells even when cells are widely separated and have different intrinsic frequencies of oscillation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.