ArticleThe Plant cell2005
Arabidopsis SENESCENCE-ASSOCIATED GENE101 stabilizes and signals within an ENHANCED DISEASE SUSCEPTIBILITY1 complex in plant innate immunity.
Article in The Plant cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers.
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Who cites it
202 citing papers in PubMed.
- AtHSPR Plays a Positive Role in Arabidopsis Resistance AgainstBiomolecules · 2026Article
- Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Take control of expression: effector-mediated modulation of the host transcriptional machinery.Frontiers in plant science · 2026Review
- OsEDS1 and OsPAD4 Are Involved in Brown Planthopper Resistance in Rice.Plants (Basel, Switzerland) · 2025Article
- Phytoalexin deficient 4 is associated with the lesion mimic trait in watermelon clalm mutant (Citrullus lanatus).BMC plant biology · 2025Article
- Genome-wide identification ofFrontiers in plant science · 2025Article
- Decoding the Impact of a Bacterial Strain ofMicroorganisms · 2024Article
- A disease resistance assay in Nicotiana benthamiana reveals the immune function of Response to HopBA1.Plant physiology · 2024Article
- Pathogen perception and signaling in plant immunity.The Plant cell · 2024Review
- Defense and senescence interplay in legume nodules.Plant communications · 2024Review
- Appropriate reduction of importin-α gene expression enhances yellow dwarf disease resistance in common wheat.Plant biotechnology journal · 2024Article
- Article
- ETI signaling nodes are involved in resistance of Hawaii 7996 toPlant signaling & behavior · 2023Article
- Plasma membrane association and resistosome formation of plant helper immune receptors.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- ENHANCED DISEASE SUSCEPTIBILITY 1 promotes hydrogen peroxide scavenging to enhance rice thermotolerance.Plant physiology · 2023Article
- Absence of SICKLE triggers programed cell death by disturbing alternative splicing and decay of mRNAs.Plant physiology · 2023Article
- WheatInternational journal of molecular sciences · 2023Article
- The Arabidopsis thaliana onset of leaf death 12 mutation in the lectin receptor kinase P2K2 results in an autoimmune phenotype.BMC plant biology · 2023Article
- The flowering time regulator FLK controls pathogen defense in Arabidopsis thaliana.Plant physiology · 2023Article
- A splicing variant of EDS1 from Vitis vinifera forms homodimers but no heterodimers with PAD4.Protein science : a publication of the Protein Society · 2023Article
142 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant innate immunity against invasive biotrophic pathogens depends on the intracellular defense regulator ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1). We show here that Arabidopsis thaliana EDS1 interacts in vivo with another protein, SENESCENCE-ASSOCIATED GENE101 (SAG101), discovered through a proteomic approach to identify new EDS1 pathway components. Together with PHYTOALEXIN-DEFICIENT4 (PAD4), a known EDS1 interactor, SAG101 contributes intrinsic and indispensable signaling activity to EDS1-dependent resistance. The combined activities of SAG101 and PAD4 are necessary for programmed cell death triggered by the Toll-Interleukin-1 Receptor type of nucleotide binding/leucine-rich repeat immune receptor in response to avirulent pathogen isolates and in restricting the growth of normally virulent pathogens. We further demonstrate by a combination of cell fractionation, coimmunoprecipitation, and fluorescence resonance energy transfer experiments the existence of an EDS1-SAG101 complex inside the nucleus that is molecularly and spatially distinct from EDS1-PAD4 associations in the nucleus and cytoplasm. By contrast, EDS1 homomeric interactions were detected in the cytoplasm but not inside the nucleus. These data, combined with evidence for coregulation between individual EDS1 complexes, suggest that dynamic interactions of EDS1 and its signaling partners in multiple cell compartments are important for plant defense signal relay.
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