ArticleNucleic acids research2005
Length-dependent energetics of (CTG)n and (CAG)n trinucleotide repeats.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Structural polymorphism of the nucleic acids in pentanucleotide repeats associated with the neurological disorder CANVAS.The Journal of biological chemistry · 2024Article
- Frustration Between Preferred States of Complementary Trinucleotide Repeat DNA Hairpins Anticorrelates with Expansion Disease Propensity.Journal of molecular biology · 2023Article
- Heterogeneous migration routes of DNA triplet repeat slip-outs.Biophysical reports · 2022Article
- Conformational and migrational dynamics of slipped-strand DNA three-way junctions containing trinucleotide repeats.Nature communications · 2021Article
- Decoding the Structural Dynamics and Conformational Alternations of DNA Secondary Structures by Single-Molecule FRET Microspectroscopy.Frontiers in molecular biosciences · 2021Review
- Efficient modification of λ-DNA substrates for single-molecule studies.Scientific reports · 2017Article
- Unique Length-Dependent Biophysical Properties of Repetitive DNA.The journal of physical chemistry. B · 2016Article
- Impact of bulge loop size on DNA triplet repeat domains: Implications for DNA repair and expansion.Biopolymers · 2014Article
- CAG/CTG repeats alter the affinity for the histone core and the positioning of DNA in the nucleosome.Biochemistry · 2012Article
- Energy landscapes of dynamic ensembles of rolling triplet repeat bulge loops: implications for DNA expansion associated with disease states.Journal of the American Chemical Society · 2012Article
- Trinucleotide repeat DNA alters structure to minimize the thermodynamic impact of 8-oxo-7,8-dihydroguanine.Biochemistry · 2012Article
- Premutation huntingtin allele adopts a non-B conformation and contains a hot spot for DNA damage.Biochemical and biophysical research communications · 2011Article
- Structure of even/odd trinucleotide repeat sequences modulates persistence of non-B conformations and conversion to duplex.Biochemistry · 2011Article
- Sequence length dictates repeated CAG folding in three-way junctions.Biochemistry · 2011Article
- Continuous and periodic expansion of CAG repeats in Huntington's disease R6/1 mice.PLoS genetics · 2010Article
- Context dependence of trinucleotide repeat structures.Biochemistry · 2010Article
- Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad.Nucleic acids research · 2009Article
- Stability of intramolecular quadruplexes: sequence effects in the central loop.Nucleic acids research · 2009Article
- DNA repair and DNA triplet repeat expansion: the impact of abasic lesions on triplet repeat DNA energetics.Journal of the American Chemical Society · 2009Article
- Structural studies of a trinucleotide repeat sequence using 2-aminopurine.Biochemistry · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trinucleotide repeats are involved in a number of debilitating diseases such as myotonic dystrophy. Twelve to seventy-five base-long (CTG)n oligodeoxynucleotides were analysed using a combination of biophysical [UV-absorbance, circular dichroism and differential scanning calorimetry (DSC)] and biochemical methods (non-denaturing gel electrophoresis and enzymatic footprinting). All oligomers formed stable intramolecular structures under near physiological conditions with a melting temperature that was only weakly dependent on oligomer length. Thermodynamic analysis of the denaturation process by UV-melting and calorimetric experiments revealed an unprecedented length-dependent discrepancy between the enthalpy values deduced from model-dependent (UV-melting) and model-independent (calorimetry) experiments. Evidence for non-zero molar heat capacity changes was also derived from the analysis of the Arrhenius plots and DSC profiles. Such behaviour is analysed in the framework of an intramolecular 'branched-hairpin' model, in which long CTG oligomers do not fold into a simple long hairpin-stem intramolecular structure, but allow the formation of several independent folding units of unequal stability. We demonstrate that, for sequences ranging from 12 to 25 CTG repeats, an intramolecular structure with two loops is formed which we will call 'bis-hairpin'. Similar results were also found for CAG oligomers, suggesting that this observation may be extended to various trinucleotide repeats-containing sequences.
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