ReviewDrugs & aging2005
Dysregulation of T-cell function in the elderly : scientific basis and clinical implications.
Review in Drugs & aging, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- Exploring the link: Hemogram-derived markers in type 2 diabetes mellitus and its complications.World journal of diabetes · 2025Review
- Assessment of Selected Immune Parameters in Patients Undergoing Cardiac Surgery with the Use of Cardiopulmonary Bypass: Aspects of Age and Sex-A Pilot Study.Biomedicines · 2023Article
- 3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome.Cellular and molecular life sciences : CMLS · 2022Article
- The ocular surface immune system through the eyes of aging.The ocular surface · 2021Review
- Article
- CMV-Specific T-cell Responses at Older Ages: Broad Responses With a Large Central Memory Component May Be Key to Long-term Survival.The Journal of infectious diseases · 2017Article
- Premature T Cell Senescence in Pediatric CKD.Journal of the American Society of Nephrology : JASN · 2017Article
- Mitochondrial Dysfunction in Alzheimer's Disease and the Rationale for Bioenergetics Based Therapies.Aging and disease · 2016Review
- Preexisting Immunity, More Than Aging, Influences Influenza Vaccine Responses.Open forum infectious diseases · 2015Article
- Cardio-metabolic and immunological impacts of extra virgin olive oil consumption in overweight and obese older adults: a randomized controlled trial.Nutrition & metabolism · 2015Article
- A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways.Scientific reports · 2014Article
- The pathology and pathogenesis of experimental severe acute respiratory syndrome and influenza in animal models.Journal of comparative pathology · 2014Review
- Article
- Immunosenescence in the nursing home elderly.BMC geriatrics · 2014Article
- Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly.Cell communication and signaling : CCS · 2014Article
- Immunomodulatory role of high-density lipoproteins: impact on immunosenescence.Age (Dordrecht, Netherlands) · 2014Article
- Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents.PloS one · 2014Article
- Immunosenescence and organ transplantation.Transplantation reviews (Orlando, Fla.) · 2013Review
- Parity-dependent association between TNF-α and LTF gene polymorphisms and clinical mastitis in dairy cattle.BMC veterinary research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The function of the immune system is to maintain body integrity by defending against infections, cancers, autoimmune diseases and inflammation-related chronic diseases. The immune response is known to become defective with aging, leading to decreased longevity and appearance of age-related disease. The most important changes occur in T-cell immunity, and are manifested particularly as altered clonal expansion of cells of limited antigen specificity. The causes of these alterations are multifactorial, and include thymic involution, T-cell subset changes and signal transduction alterations. The clinical consequences of these changes are not well defined, except for their extremely important negative impact on defence against infections, especially by new pathogens, and decreased responses to vaccination. Considering the public health consequences of decreased immune competence in old age, strategies for immune response modulation are desirable to decrease the health burden for the elderly and improve their quality of life.
Indexed as
Identifiers
16038574What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.