ArticleCell stress & chaperones2005
Plasma antibodies to heat shock protein 60 and heat shock protein 70 are associated with increased risk of electrocardiograph abnormalities in automobile workers exposed to noise.
Article in Cell stress & chaperones, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The prevalence of occupational exposure to noise: A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury.Environment international · 2021Pooled it
- Former CSSI President Tangchun Wu elected to the Chinese Academy of Engineering.Cell stress & chaperones · 2022Article
- Different Types of Sounds and Their Relationship With the Electrocardiographic Signals and the Cardiovascular System - Review.Frontiers in physiology · 2018Review
- Significance of serum antibodies against HSP 60 and HSP 70 for the diagnostic of infectious diseases.Virulence · 2014Article
- Evidence of a role for both anti-Hsp70 antibody and endothelial surface membrane Hsp70 in atherosclerosis.Cell stress & chaperones · 2013Article
- Autoimmunoreactive IgGs against cardiac lipid raft-associated proteins in patients with postural orthostatic tachycardia syndrome.Translational research : the journal of laboratory and clinical medicine · 2013Article
- Antiplatelet effects of qishen yiqi dropping pill in platelets aggregation in hyperlipidemic rabbits.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Plasma levels of Hsp70 and anti-Hsp70 antibody predict risk of acute coronary syndrome.Cell stress & chaperones · 2010Article
- Circulating anti-heat-shock-protein antibodies in normal pregnancy and preeclampsia.Cell stress & chaperones · 2009Article
- Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers.Cell stress & chaperones · 2006Article
- Antibodies against heat shock proteins in environmental stresses and diseases: friend or foe?Cell stress & chaperones · 2006Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the living and working environment, stressful factors, such as noise, can cause health problems including cardiovascular diseases and noise-induced hearing loss. Some heat shock proteins (Hsps) play an important role in protecting cardiac cells against ischemic injury, and antibodies against these Hsps are associated with the development and prognosis of atherogenesis, coronary heart disease, and hypertension. Whether the presence of such antibodies is associated with abnormal electrocardiography (ECG) in stressed autoworkers exposed to chronic noise is presently unknown. Therefore, we investigated the association between the levels of plasma anti-Hsp60 and anti-Hsp70 with electrocardiograph abnormality in 396 autoworkers exposed to different noise levels by using Western blot, ECG, and multivariate logistic regression analysis. The results showed that the increase in levels of anti-Hsp70 was associated with a higher risk of ECG abnormalities characteristic of chronic myocardial ischemia (P < 0.05), conductive abnormality (P < 0.01), or heart displacement (P < 0.05); in contrast, elevated anti-Hsp60 was related to ECG abnormalities characteristic of sinus arrhythmia, chronic myocardial ischemia, and ectopic rhythm (P < 0.01 for all). Overall, high levels of both anti-Hsp70 and anti-Hsp60 were associated with significantly increased risk of ECG abnormalities (odds ratio [OR] = 1.73 and 95% confidence interval [Cl] = 1.04-2.86 for anti-Hsp70 and OR = 1.36 and 95% Cl = 1.07-1.72 for anti-Hsp60) with and without adjustment for cumulative noise exposure (OR = 1.96 and 95% Cl = 1.20-3.21 for anti-Hsp70 and OR = 3.93 and 95% Cl = 1.72-8.92 for anti-Hsp60). These findings suggest that the production of both anti-Hsp70 and anti-Hsp60 may be independent risk factors for the development and progression of abnormal ECG and therefore possibly cardiovascular diseases in autoworkers exposed to occupational noise.
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