ArticleWorld journal of gastroenterology2005
Effects of magnolol and honokiol derived from traditional Chinese herbal remedies on gastrointestinal movement.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Traditional herbal medicine for opioid-induced constipation in patients with cancer: a systematic review and meta-analysis of randomized controlled trials.Frontiers in pharmacology · 2025Pooled it
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- What can traditional plant therapy do in the face of Covid-19? Examples from traditional Chinese medicine.African health sciences · 2023Article
- Protective effects of Liupao tea against high-fat diet/cold exposure-induced irritable bowel syndrome in rats.Heliyon · 2023Article
- An In Vitro and In Silico Characterization ofPharmaceutics · 2023Article
- Article
- The Therapeutic Effects of Magnolia Officinalis Extraction on an Antibiotics-Induced Intestinal Dysbacteriosis in Mice.Current microbiology · 2020Article
- Gastrointestinal Motility and Improvement Efficacy of Shenhuang Plaster Application on Shenque: Identification, Evaluation, and Mechanism.Journal of immunology research · 2020Article
- Usefulness of a Kampo Medicine on Stress-Induced Delayed Gastric Emptying in Mice.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Metabolomics Analysis of L-Arginine Induced Gastrointestinal Motility Disorder in Rats Using UPLC-MS After Magnolol Treatment.Frontiers in pharmacology · 2019Article
- Systems Pharmacology Dissection of Multi-Scale Mechanisms of Action ofFrontiers in pharmacology · 2018Article
- Antioxidant Phytochemicals ofPharmacognosy magazine · 2017Article
- Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice.Molecules (Basel, Switzerland) · 2017Article
- Metabolic regulation of magnolol on the nuclear receptor, liver X receptor.Experimental and therapeutic medicine · 2015Article
- In Vitro Impact of Hydro-alcoholic Extract of Rosa damascena Mill. on Rat Ileum Contractions and the Mechanisms Involved.International journal of preventive medicine · 2014Article
- HEF-19-induced relaxation of colonic smooth muscles and the underlying mechanisms.World journal of gastroenterology · 2013Article
- Magnolol pretreatment prevents sepsis-induced intestinal dysmotility by maintaining functional interstitial cells of Cajal.Inflammation · 2013Article
- Tibetan herbal formula Padma Digestin modulates gastrointestinal motility in vitro.World journal of gastrointestinal pharmacology and therapeutics · 2013Article
- Spasmolytic effect of stachys lavandulifolia vahl. Crude methanolic extract and fractions on rat ileum.Iranian journal of pharmaceutical research : IJPR · 2011Article
- Antispasmodic effects of Citrus aurantium flowers aqueous extract on uterus of non-pregnant rats.Iranian journal of reproductive medicine · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the effects of magnolol and honokiol on isolated smooth muscle of gastrointestinal tract and their relationship with Ca2+, and on the gastric emptying and the intestinal propulsive activity in mice.
methodsRoutine experimental methods using isolated gastric fundus strips of rats and isolated ileum segments of guinea pigs were adopted to measure the smooth muscle tension. The effects of magnolol 10(-3), 10(-4), 10(-5) mol/L, and honokiol 10(-4), 10(-5), 10(-6) mol/L on the contractility of gastric fundus strips of rats and ileum of guinea pigs induced by acetylcholine (Ach) and 5-hydroxytryptamine (5-HT) was assessed respectively. The method using nuclein and pigment methylene blue was adopted to measure the gastric retention rate of nuclein and the intestinal propulsive ratio of a nutritional semi-solid meal for assessing the effect of magnolol and honokiol (0.5, 2, 20 mg/kg) on gastric emptying and intestinal propulsion.
resultsMagnolol and honokiol significantly inhibited the contractility of isolated gastric fundus strips of rats treated with Ach or 5-HT and isolated ileum guinea pigs treated with Ach or CaCl2, and both of them behaved as non-competitive muscarinic antagonists. Magnolol and honokiol inhibited the contraction induced by Ach in Ca2+-free medium and extracellular Ca2+-dependent contraction induced by Ach. Each group of magnolol and honokiol experiments significantly decreased the residual rate of nuclein in the stomach and increased the intestinal propulsive ratio in mice.
conclusionThe inhibitory effect of magnolol and honokiol on contractility of the smooth muscles of isolated gastric fundus strips of rats and isolated ileum of guinea pigs is associated with a calcium-antagonistic effect. Magnolol and honokiol can improve the gastric emptying of a semi-solid meal and intestinal propulsive activity in mice.
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