ArticleThe Journal of physiology2005
Balance between cardiac output and sympathetic nerve activity in resting humans: role in arterial pressure regulation.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.
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Who cites it
126 citing papers in PubMed, 248 citations in OpenAlex.
- Trial
- Increase in diastolic blood pressure induced by fragrance inhalation of grapefruit essential oil is positively correlated with muscle sympathetic nerve activity.The journal of physiological sciences : JPS · 2020Trial
- Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Resting regional brain activity and connectivity vary with resting blood pressure but not muscle sympathetic nerve activity in normotensive humans: An exploratory study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Trial
- Attenuation of hypertension by C-fiber stimulation of the human median nerve and the concept-based novel device.Scientific reports · 2018Trial
- The Role of the Autonomic Nervous System in the Regulation of Aortic Stiffness.Hypertension (Dallas, Tex. : 1979) · 2016Trial
- Aging enhances autonomic support of blood pressure in women.Hypertension (Dallas, Tex. : 1979) · 2014Trial
- Sex differences in carotid baroreflex control of arterial blood pressure in humans: relative contribution of cardiac output and total vascular conductance.American journal of physiology. Heart and circulatory physiology · 2011Trial
- Effect of phenylephrine and ephedrine bolus treatment on cerebral oxygenation in anaesthetized patients.British journal of anaesthesia · 2011Trial
- Age-related differences in the sympathetic-hemodynamic balance in men.Hypertension (Dallas, Tex. : 1979) · 2009Trial
- Hemodynamic determinants of chronic hypotension and their modification through vasopressor application.The journal of physiological sciences : JPS · 2009Trial
- Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Trial
- Novel Advances in Our Understanding of Sex-Dependent Control of Blood Pressure.Annual review of physiology · 2026Review
- The effect of sex on the isolated and combined α- and β-adrenergic control of blood flow during handgrip in adults at high altitude: An exploratory study.Physiological reports · 2026Article
- Autonomic control of blood pressure in women: The roles of hypertension and aging.Autonomic neuroscience : basic & clinical · 2025Review
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Review
- Non-additive effects of electrical stimulation of the dorsolateral prefrontal cortex and the vestibular system on muscle sympathetic nerve activity in humans.Experimental brain research · 2024Article
- Dynamic cerebral autoregulation is preserved during orthostasis and intrathoracic pressure regulation in healthy subjects: A pilot study.Physiological reports · 2024Article
- Higher Cardiovagal Baroreflex Sensitivity Predicts Increased Pain Outcomes After Cardiothoracic Surgery.The journal of pain · 2024Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Large, reproducible interindividual differences exist in resting sympathetic nerve activity among normotensive humans with similar arterial pressures, resulting in a lack of correlation between muscle sympathetic nerve activity (MSNA) and arterial pressure among individuals. Although it is known that the arterial pressure is the main short-term determinant of MSNA in humans via the arterial baroreflex, the lack of correlation among individuals suggests that the level of arterial pressure is not the only important input in regulation of MSNA in humans. We studied the relationship between cardiac output (CO) and baroreflex control of sympathetic activity by measuring MSNA (peroneal microneurography), arterial pressure (arterial catheter), CO (acetylene uptake technique) and heart rate (HR; electrocardiogram) in 17 healthy young men during 20 min of supine rest. Across individuals, MSNA did not correlate with mean or diastolic blood pressure (r<0.01 for both), but displayed a significant negative correlation with CO (r=-0.71, P=0.001). To assess whether CO is related to arterial baroreflex control of MSNA, we constructed a baroreflex threshold diagram for each individual by plotting the percentage occurrence of a sympathetic burst against diastolic pressure. The mid-point of the diagram (T50) at which 50% of cardiac cycles are associated with bursts, was inversely related to CO (r=-0.75, P<0.001) and stroke volume (SV) (r=-0.57, P=0.015). We conclude that dynamic inputs from CO and SV are important in regulation of baroreflex control of MSNA in healthy, normotensive humans. This results in a balance between CO and sympathetically mediated vasoconstriction that may contribute importantly to normal regulation of arterial pressure in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.