ArticleJournal of neurovirology2005
T cell-mediated restriction of intracerebral murine cytomegalovirus infection displays dependence upon perforin but not interferon-gamma.
Article in Journal of neurovirology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Persistent microglial activation following neonatal CMV infection mediates neurodegeneration.Science advances · 2026Article
- Immune responses drive chorioretinitis and retinal pathology after neonatal CMV infection.Science advances · 2024Article
- Murine Models of Central Nervous System Disease following Congenital Human Cytomegalovirus Infections.Pathogens (Basel, Switzerland) · 2021Review
- Glial Cell Expression of PD-L1.International journal of molecular sciences · 2019Review
- Glial cell activation, recruitment, and survival of B-lineage cells following MCMV brain infection.Journal of neuroinflammation · 2016Article
- Chronic reactive gliosis following regulatory T cell depletion during acute MCMV encephalitis.Glia · 2015Article
- Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model.Cellular & molecular immunology · 2015Review
- Tregs Modulate Lymphocyte Proliferation, Activation, and Resident-Memory T-Cell Accumulation within the Brain during MCMV Infection.PloS one · 2015Article
- Infiltrating regulatory B cells control neuroinflammation following viral brain infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Persistent humoral immune responses in the CNS limit recovery of reactivated murine cytomegalovirus.PloS one · 2012Article
- Memory T cells persisting in the brain following MCMV infection induce long-term microglial activation via interferon-γ.Journal of neurovirology · 2011Article
- Reduced lymphocyte infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice.Journal of neurovirology · 2009Article
- Neuropathogenesis of congenital cytomegalovirus infection: disease mechanisms and prospects for intervention.Clinical microbiology reviews · 2009Review
- Cytomegalovirus infection and interferon-gamma modulate major histocompatibility complex class I expression on neural stem cells.Journal of neurovirology · 2008Article
- Dysregulated interferon-gamma responses during lethal cytomegalovirus brain infection of IL-10-deficient mice.Virus research · 2007Article
- Differential responses of human brain cells to West Nile virus infection.Journal of neurovirology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The authors have previously reported that adoptive transfer of splenocytes suppresses murine cytomegalovirus (MCMV) brain infection following intracerebroventricular injection of immunodeficient mice and that depletion of Thy 1.2+ T lymphocytes abolishes this suppressive effect. Here the authors report that splenocytes depleted of CD4+ T lymphocytes prior to adoptive transfer retained their ability to control viral expression in the brain. In sharp contrast, depletion of the CD8+ T-cell population prior to transfer abolished the suppressive effect, with sixfold greater expression in the brain than when undepleted splenocytes were used. The authors went on to examine the contributions of cytokine- and perforin-mediated mechanisms in controlling MCMV brain infection using splenocytes from major histocompatibility (MHC)-matched IFN-gamma -knockout (GKO), and perforin-knockout (PKO) mice. When used in adoptive transfer studies, splenocytes from GKO mice controlled viral expression; however, cells from PKO mice could not control reporter gene expression or viral DNA replication in brain tissues. The authors have previously reported that the levels of the T-cell chemoattractant CXCL10 are highly elevated in the brains of MCMV-infected mice. Here the authors found that the receptor for this ligand, CXCR3, was not essential in mediating the suppressive effects of adoptive transfer. These data indicate that peripheral CD8+ T cells control MCMV brain infection through a perforin-mediated mechanism and that neither IFN-gamma nor CXCR3 play a critical role in this neuroprotective response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.