SynthesisThe Cochrane database of systematic reviews2005
Carbamazepine for acute and chronic pain.
Synthesis in The Cochrane database of systematic reviews, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03580317 (Electroacupuncture Therapy for Change of Pain in Classical Trigeminal Neuralgia), which is not on this map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Electroacupuncture Therapy for Change of Pain in Classical Trigeminal Neuralgia
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 179 citations in OpenAlex.
- Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury.The Cochrane database of systematic reviews · 2020Pooled it
- Antiepileptic drugs for the treatment of neuropathic pain: a systematic review.Medicina oral, patologia oral y cirugia bucal · 2012Pooled it
- Pregabalin for acute and chronic pain in adults.The Cochrane database of systematic reviews · 2009Pooled it
- Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials.BMC neurology · 2008Pooled it
- Trial
- A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis.Journal of neurology · 2013Trial
- Use of a lidocaine patch in the management of postsurgical neuropathic pain in patients with cancer: a phase III double-blind crossover study (N01CB).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2009Trial
- Review
- Paving the way for a better management of pain in patients with spinal cord injury: An exploratory study on the use of Functional Electric Stimulation(FES)-cycling.The journal of spinal cord medicine · 2023Article
- Gamma Knife Radiosurgery on the Trigeminal Root Entry Zone for Idiopathic Trigeminal Neuralgia: Results and a Review of the Literature.Yonsei medical journal · 2020Review
- Article
- Pharmacological treatment of diabetic peripheral neuropathy.P & T : a peer-reviewed journal for formulary management · 2015Article
- Update on neuropathic pain treatment for trigeminal neuralgia. The pharmacological and surgical options.Neurosciences (Riyadh, Saudi Arabia) · 2015Review
- Frame and frameless linear accelerator-based radiosurgery for idiopathic trigeminal neuralgia.Journal of radiosurgery and SBRT · 2015Article
- Advances in diagnosis and treatment of trigeminal neuralgia.Therapeutics and clinical risk management · 2015Review
- Natural history and outcome of 200 outpatients with classical trigeminal neuralgia treated with carbamazepine or oxcarbazepine in a tertiary centre for neuropathic pain.The journal of headache and pain · 2014Article
- Surgical treatment of pediatric trigeminal neuralgia: case series and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2011Review
- Trigeminal Neuralgia - A Debilitating Facial Pain.Reviews in pain · 2011Article
- Treatment of a patient with glossopharyngeal neuralgia by the anterior tonsillar pillar method.Case reports in neurology · 2011Article
- Treatment of trigeminal neuralgia: role of radiofrequency ablation.Journal of pain research · 2010Article
Corrections and comments
- Updated by
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnticonvulsant drugs have been used in the management of pain since the 1960s. The clinical impression is that they are useful for chronic neuropathic pain, especially when the pain is lancinating or burning.
objectivesTo evaluate the analgesic effectiveness and adverse effects of the anticonvulsant medicine carbamazepine for pain management in clinical practice and to identify a clinical research agenda. Migraine and headache studies are not included in this review. SEARCH STRATEGY: Randomised trials (RCTs) of anticonvulsants in acute, chronic or cancer pain were identified by MEDLINE (1966-2004), EMBASE (1994-2004), SIGLE (1980-2004) and the Cochrane Controlled Trials Register (CENTRAL/CCTR) (Cochrane Library Issue 3, 2003). In addition, 41 medical journals were hand searched for a previous version of this review. Additional reports were identified from the reference list of the retrieved papers, and by contacting investigators. Date of most recent search: November 2004. SELECTION CRITERIA: Randomised trials reporting the analgesic effects of carbamazepine in patients, with subjective pain assessment as either the primary or a secondary outcome. DATA COLLECTION AND ANALYSIS: Data were extracted by two independent reviewers, and trials were quality scored. Numbers-needed-to-treat (NNTs) were calculated from dichotomous data for effectiveness, adverse effects and drug-related study withdrawal, for individual studies and for pooled data. MAIN
resultsTwelve studies were included (404 participants). Four studies included trigeminal neuralgia patients. Two studies which provided evaluable data yielded an NNT for effectiveness of 1.8 (95%CI 1.4-2.8). For diabetic neuropathy there was insufficient data for an NNT to be calculated.Numbers-needed-to-harm (NNHs) were calculated where possible by combining studies for each drug entity irrespective of the condition treated. The results were, for minor harm, carbamazepine 3.7 (CI 2.4-7.8), NNHs for major harm were not statistically significant for carbamazepine compared with placebo. There is no evidence that carbamazepine is effective for acute pain. AUTHORS'
conclusionsThere is evidence to show that carbamazepine is effective but trials are small.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.