ReviewGenes and immunity2005
Genes and (auto)immunity in primary biliary cirrhosis.
Review in Genes and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Infliximab as a treatment option for patients with rheumatoid arthritis and primary biliary cirrhosis.Rheumatology international · 2015Review
- The immunogenetics of primary biliary cirrhosis: A comprehensive review.Journal of autoimmunity · 2015Review
- Genetic polymorphisms of OCT-1 confer susceptibility to severe progression of primary biliary cirrhosis in Japanese patients.Journal of gastroenterology · 2014Article
- Presence of disease specific autoantibodies against liver sinusoidal cells in primary biliary cirrhosis.World journal of hepatology · 2013Article
- Tracing environmental markers of autoimmunity: introducing the infectome.Immunologic research · 2013Review
- Infectome: a platform to trace infectious triggers of autoimmunity.Autoimmunity reviews · 2013Review
- Pathway-based analysis of primary biliary cirrhosis genome-wide association studies.Genes and immunity · 2013Article
- Predicting and preventing autoimmunity: the case of anti-mitochondrial antibodies.Auto- immunity highlights · 2012Review
- The X-factor in primary biliary cirrhosis: monosomy X and xenobiotics.Auto- immunity highlights · 2012Review
- Autoimmune hepatitis type 2 associated with an unexpected and transient presence of primary biliary cirrhosis-specific antimitochondrial antibodies: a case study and review of the literature.BMC gastroenterology · 2012Review
- Generation of a cholangiocyte-specific cDNA expression library for the identification of B and T cell autoantigens in murine biliary disease.Hepatology research : the official journal of the Japan Society of Hepatology · 2012Article
- Autoimmunity and environment: am I at risk?Clinical reviews in allergy & immunology · 2012Review
- Towards systemic sclerosis and away from primary biliary cirrhosis: the case of PTPN22.Auto- immunity highlights · 2012Review
- Sex differences associated with primary biliary cirrhosis.Clinical & developmental immunology · 2012Review
- A polymorphism in the integrin αV subunit gene affects the progression of primary biliary cirrhosis in Japanese patients.Journal of gastroenterology · 2011Article
- Primary biliary cirrhosis: family stories.Autoimmune diseases · 2011Article
- Primary biliary cirrhosis.Seminars in immunopathology · 2009Review
- Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity.Hepatology (Baltimore, Md.) · 2009Article
- Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene.Gastroenterology · 2008Article
- The unfinished business of primary biliary cirrhosis.Journal of hepatology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary biliary cirrhosis (PBC) is a chronic autoimmune cholestatic liver disease most commonly encountered in postmenopausal women; it is characterized by high-titer serum autoantibodies to mitochondrial antigens, elevated serum IgM, progressive destruction of intrahepatic bile ducts, and ultimately liver cirrhosis and failure. The cytopathic mechanisms leading to the selective destruction of intrahepatic cholangiocytes are still largely unknown. The current theory on the pathogenesis of PBC indicated that environmental factors might trigger autoimmunity in genetically susceptible individuals. In fact, genetic predisposition is critical to disease onset and progression, yet peculiar among autoimmune diseases, as indicated by the lack of a strong association with major histocompatibility complex haplotypes. Further, the recently reported concordance rate among monozygotic twins strengthens the importance of genetic factors, while also indicating that additional factors, possibly infectious agents or xenobiotics, intervene to trigger the disease. In this review, the available data regarding the genetic factors associated with PBC susceptibility and progression, as well as the available evidence regarding the immunomediated pathogenesis of PBC, will be critically illustrated and discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.