ReviewNature reviews. Immunology2005
Two sides of a cellular coin: CD4(+)CD3- cells regulate memory responses and lymph-node organization.
Review in Nature reviews. Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 76 citations in OpenAlex.
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- Diagnostic nomogram based on ultrasound and clinical data of predicting malignant lymph nodes in HIV patients with lymphadenopathy.Frontiers in cellular and infection microbiology · 2025Article
- Immune Responses Induced by a RecombinantViruses · 2024Article
- Lymphoid tissue inducer cells in cancer: a potential therapeutic target.Molecular and cellular biochemistry · 2023Review
- Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina.Molecular therapy. Methods & clinical development · 2021Article
- Phenotypical Characterization of Spleen Remodeling in Murine Experimental Visceral Leishmaniasis.Frontiers in immunology · 2020Article
- Lymphoid tissue inducer-A divergent member of the ILC family.Cytokine & growth factor reviews · 2018Review
- Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation.Frontiers in immunology · 2017Review
- CD30 Is Dispensable for T-Cell Responses to Influenza Virus and Lymphocytic Choriomeningitis Virus Clone 13 but Contributes to Age-Associated T-Cell Expansion in Mice.Frontiers in immunology · 2017Article
- CD30 is required for activation of a unique subset of interleukin-17A-producing γδ T cells in innate immunity against Mycobacterium bovis Bacillus Calmette-Guerin infection.Infection and immunity · 2013Article
- Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo.Blood · 2012Article
- Evaluation of serum levels of sCD30L ligand in patients with ovarian cancer in terms of selected clinico-pathological factors.Contemporary oncology (Poznan, Poland) · 2012Article
- Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?Frontiers in immunology · 2012Article
- Natural killer cell receptor-expressing innate lymphocytes: more than just NK cells.Cellular and molecular life sciences : CMLS · 2011Review
- Article
- The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling.Nature immunology · 2011Review
- Heterogeneity of IL-22-producing Lymphoid Tissue Inducer-like Cells in Human and Mouse.Immune network · 2010Article
- Signals that influence T follicular helper cell differentiation and function.Seminars in immunopathology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
We propose that CD4(+)CD3(-) cells have two functions: a well-established role in organizing lymphoid tissue during development, and a newly discovered role in supporting T-cell help for B cells both during affinity maturation in germinal centres and for memory antibody responses. As CD4(+)CD3(-) cells express the HIV co-receptors CD4 and CXC-chemokine receptor 4, we think that infection of these cells by HIV, and their subsequent destruction by the host immune system, could help to explain the loss of memory antibody responses and the destruction of lymphoid architecture that occur during disease progression to AIDS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.