Evidence map›Paper›PMID 16034179›Full record

ReviewEndocrine2005

Gonadotropin receptors: role of post-translational modifications and post-transcriptional regulation.

K M J Menon, Christine L Clouser, Anil K Nair

Abstract readReview
PubMed Publisher
In one paragraph

Review in Endocrine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

K M J MenonDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, 48109-0617, USA. kmjmenon@umich.edu
Christine L Clouser
Anil K Nair
University of Michigan–Ann Arbor · USOffice of Basic Energy Sciences · US

Funding

Cellular Biotechnology Training Program (CBTP)T32GM008353 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHWENDEMAN, ANNA · 1991 to 2021
$9.3M
Regulation Of Ovarian Function By GonadotropinR37HD006656 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MENON, JAIRAM K.M. · 2002 to 2011
$3.0M
Cellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6M
TRAINING PROGRAM IN REPRODUCTIVE ENDOCRINOLOGYT32HD007048 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SMITH, GARY DANIEL · 1985 to 2009
$2.6M
NICHD NIH HHS 5 T32 HD07048NICHD NIH HHS R37-HD-06656NIGMS NIH HHS T32 GM145304NIGMS NIH HHS T3 GM 08353
6 · The paper itself

Abstract

This review focuses on the post-translational modifications of LH and FSH receptors and recent studies on the regulation of LH receptor expression mediated by an RNA binding protein. Both LH and FSH receptors undergo extensive post-translational modifications. N-linked glycosylation occurs co-translationally and plays a role in the maturation and processing of the receptor, while palmitoylation is involved in receptor endocytosis and post-endocytic trafficking. A third type of post-translational modification is phosphorylation and its function has been reviewed. Finally, the regulation of LH receptor at the mRNA level by an RNA binding protein is discussed in the context of ovarian function.

Indexed as

AnimalsGene Expression RegulationGlycosylationHumansPalmitatesPhosphorylationProtein Processing, Post-TranslationalProtein TransportReceptors, FSHReceptors, LHRNA, MessengerTranscription, GeneticPalmitatesReceptors, FSHReceptors, LHRNA, Messenger

Identifiers

PMID16034179
OpenAlexW2091081492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.