ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed, 173 citations in OpenAlex.
- Impact of morphometry, myelinization and synaptic current strength on spike conduction in human and cat spiral ganglion neurons.PloS one · 2013Trial
- Cochlear aging after synaptopathic noise: age-noise interactions in hair cell loss and axonal degeneration.Hearing research · 2026Article
- Voltage-gated sodium channels in the nervous system: Molecular physiology to therapeutic interventions.Neural regeneration research · 2026Article
- Distribution of Voltage-Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment.The Journal of comparative neurology · 2026Article
- Cochlear neural functional competence: an integrative transcriptomic module analysis of excitability, plasticity and microenvironmental support programs.Frontiers in cellular neuroscience · 2026Article
- A modiolar-pillar gradient in auditory-nerve dendritic length: A novel post-synaptic contribution to dynamic range?Hearing research · 2025Article
- Simulated auditory nerve response evoked by lateral-wall and peri-modiolar electrode arrays inserted in scala tympani or scala vestibuli.Frontiers in neuroscience · 2025Article
- Hidden hearing loss in a Charcot-Marie-Tooth type 1A mouse model.JCI insight · 2024Article
- Understanding the impact of modiolus porosity on stimulation of spiral ganglion neurons by cochlear implants.Scientific reports · 2024Article
- Demyelination and NaeNeuro · 2024Article
- Peripheral Auditory Nerve Impairment in a Mouse Model of Syndromic Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Dopaminergic and cholinergic innervation in the mouse cochlea after noise-induced or age-related synaptopathy.Hearing research · 2022Article
- Low-voltage Activating KExperimental neurobiology · 2022Article
- Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiological reviews · 2022Review
- Diverse identities and sites of action of cochlear neurotransmitters.Hearing research · 2022Review
- Amplification of input differences by dynamic heterogeneity in the spiral ganglion.Journal of neurophysiology · 2022Article
- Two distinct types of nodes of Ranvier support auditory nerve function in the mouse cochlea.Glia · 2022Article
- Analog transmission of action potential fine structure in spiral ganglion axons.Journal of neurophysiology · 2021Article
- Encoding sound in the cochlea: from receptor potential to afferent discharge.The Journal of physiology · 2021Review
- SCN11A gene deletion causes sensorineural hearing loss by impairing the ribbon synapses and auditory nerves.BMC neuroscience · 2021Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The origin of the action potential in the cochlea has been a long-standing puzzle. Because voltage-dependent Na+ (Nav) channels are essential for action potential generation, we investigated the detailed distribution of Nav1.6 and Nav1.2 in the cochlear ganglion, cochlear nerve, and organ of Corti, including the type I and type II ganglion cells. In most type I ganglion cells, Nav1.6 was present at the first nodes flanking the myelinated bipolar cell body and at subsequent nodes of Ranvier. In the other ganglion cells, including type II, Nav1.6 clustered in the initial segments of both of the axons that flank the unmyelinated bipolar ganglion cell bodies. In the organ of Corti, Nav1.6 was localized in the short segments of the afferent axons and their sensory endings beneath each inner hair cell. Surprisingly, the outer spiral fibers and their sensory endings were well labeled beneath the outer hair cells over their entire trajectory. In contrast, Nav1.2 in the organ of Corti was localized to the unmyelinated efferent axons and their endings on the inner and outer hair cells. We present a computational model illustrating the potential role of the Nav channel distribution described here. In the deaf mutant quivering mouse, the localization of Nav1.6 was disrupted in the sensory epithelium and ganglion. Together, these results suggest that distinct Nav channels generate and regenerate action potentials at multiple sites along the cochlear ganglion cells and nerve fibers, including the afferent endings, ganglionic initial segments, and nodes of Ranvier.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.