ArticleBMC microbiology2005
Characterization of Pseudomonas aeruginosa isolated from chronically infected children with cystic fibrosis in India.
Article in BMC microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Available evidence of antibiotic resistance from extended-spectrum β-lactamase-producing Enterobacteriaceae in paediatric patients in 20 countries: a systematic review and meta-analysis.Bulletin of the World Health Organization · 2019Pooled it
- A novel cystic fibrosis-mimetic Pseudomonas auxotrophic vaccine is protective in vivo and is associated with IL-17/IgA mucosal Immunity.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Hidden risks of biofilm-forming and multidrug-resistant Gram-negative bacteria in water vending machines.Antonie van Leeuwenhoek · 2025Article
- Article
- Distinction of Different Colony Types by a Smart-Data-Driven Tool.Bioengineering (Basel, Switzerland) · 2022Article
- The Impact of Chlorine Disinfection of Hospital Wastewater on Clonal Similarity and ESBL-Production in Selected Bacteria of the Family Enterobacteriaceae.International journal of environmental research and public health · 2022Article
- Antibiotic resistance pattern ofGerms · 2021Article
- Metabolic and genetic basis for auxotrophies in Gram-negative species.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Prevalence, Virulence, Antimicrobial Resistance, and Molecular Characterization ofFrontiers in microbiology · 2020Article
- Pseudomonas aeruginosa Diversification during Infection Development in Cystic Fibrosis Lungs-A Review.Pathogens (Basel, Switzerland) · 2014Review
- Twenty-five-year outbreak of Pseudomonas aeruginosa infecting individuals with cystic fibrosis: identification of the prairie epidemic strain.Journal of clinical microbiology · 2014Article
- Phenotypic characterization and PCR-Ribotypic profile of Pseudomonas aeruginosa isolated from cystic fibrosis patients in Iran.Advanced biomedical research · 2013Article
- Starvation, together with the SOS response, mediates high biofilm-specific tolerance to the fluoroquinolone ofloxacin.PLoS genetics · 2013Article
- Pseudomonas aeruginosa syntrophy in chronically colonized airways of cystic fibrosis patients.Antimicrobial agents and chemotherapy · 2012Article
- Pseudomonas aeruginosa infections in patients, hospital means, and personnel's specimens.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- Nutritional requirement among Pseudomonas aeruginosa isolates recovered from respiratory clinical specimens at a tertiary hospital from South of Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011Article
- Molecular epidemiology of a Pseudomonas aeruginosa hospital outbreak driven by a contaminated disinfectant-soap dispenser.PloS one · 2011Article
- VEB-1 in Achromobacter xylosoxidans from cystic fibrosis patient, France.Emerging infectious diseases · 2006Article
- Article
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Abstract
backgroundPseudomonas aeruginosa is the leading cause of morbidity and mortality in patients with cystic fibrosis (CF). With chronicity of infection, the organism resides as a biofilm, shows multi-drug resistance, diversifies its colony morphology and becomes auxotrophic. The patients have been found to be colonized with multiple genotypes. The present work was carried out to characterize P. aeruginosa isolated from children with cystic fibrosis using phenotypic and genotypic methods.
resultsWe studied 56 patients with CF attending the Pediatric Chest clinic at All India Institute of Medical Sciences, New Delhi, India during August 1998-August 2001. These patients were regularly followed up at the clinic. Out of 56 patients, 27 were culture positive for P. aeruginosa where 8 were chronically infected (Group1) and 19 were intermittently colonized with the organism (Group2). Patients under Group1 had significantly higher rates of hospitalization, death and colonization with different colony morphotypes (p < 0.05). The isolates from Group1 patients were the positive producers of extended spectrum beta lactamase. A total of 5 auxotrophs were recovered from 2 patients where one was chronically infected with P. aeruginosa and the other was a recently enrolled patient. The auxotrophs had the specific requirement for methionine and arginine. Molecular typing revealed 33 ERIC-PCR (E1-E33) and 5 PCR-ribotyping (P1-P5) patterns. By ERIC-PCR, 4 patients were colonized with 2-4 genotypes and the remaining 23 patients were colonized with the single genotype.
conclusionWith chronicity of infection, P. aeruginosa becomes multidrug resistant, diversifies its colony morphology, acquires mucoidity and shows auxotrophy for amino acids. The chronically infected patients can be colonized with multiple genotypes. Thus in a particular clinical set up, high index of suspicion should be there for diagnosis of CF patients so as to prevent the delay in diagnosis and management of CF patients.
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