ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2005
Sympathetic nerve function--assessment by radioisotope dilution analysis.
Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Peripheral catecholamine systems: an evolutionary perspective.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Review
- Development of a Function-Integrative Sleeve for Medical Applications.Sensors (Basel, Switzerland) · 2019Article
- Prenatal Testosterone Exposure Decreases Aldosterone Production but Maintains Normal Plasma Volume and Increases Blood Pressure in Adult Female Rats.Biology of reproduction · 2016Article
- Cyclooxygenase-1 inhibition attenuates angiotensin II-salt hypertension and neurogenic pressor activity in the rat.American journal of physiology. Heart and circulatory physiology · 2013Article
- Neuroadrenergic dysfunction along the diabetes continuum: a comparative study in obese metabolic syndrome subjects.Diabetes · 2012Article
- Splanchnic sympathetic nerves in the development of mild DOCA-salt hypertension.American journal of physiology. Heart and circulatory physiology · 2011Article
- Mild DOCA-salt hypertension: sympathetic system and role of renal nerves.American journal of physiology. Heart and circulatory physiology · 2011Article
- Chronic angiotensin II infusion causes differential responses in regional sympathetic nerve activity in rats.Hypertension (Dallas, Tex. : 1979) · 2010Article
- Differential expression of the regulated catecholamine secretory pathway in different hereditary forms of pheochromocytoma.American journal of physiology. Endocrinology and metabolism · 2008Article
- Cardiac norepinephrine transporter protein expression is inversely correlated to chamber norepinephrine content.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Enhanced norepinephrine output during long-term desipramine treatment: a possible role for the extraneuronal monoamine transporter (SLC22A3).Journal of psychiatric research · 2008Article
- Sympathetic activation and inflammatory response in patients with subarachnoid haemorrhage.Intensive care medicine · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Radioisotope dilution measurements of norepinephrine spillover (rate of entry of the transmitter into plasma) provide more accurate assessments of sympathoneural transmitter release than allowed by measurements of plasma catecholamine concentrations alone. Measurements of total body norepinephrine spillover, as an index of global sympathetic outflow, allow effects on plasma clearance to be distinguished from effects on release of catecholamines into plasma, while spillovers from specific tissues enable examination of regionalized sympathetic responses. However, spillovers of norepinephrine represent only a fraction of the transmitter that escapes neuronal and extraneuronal uptake after release by nerves. Numerous factors may influence this fraction and measures spillovers independently of transmitter release by nerves. Modified radioisotope dilution methods for assessment of rate processes operating within and between intracellular and extracellular compartments have further improved our understanding of the relationships of norepinephrine release, uptake, spillover, turnover, and metabolism. This article reviews the breadth of information about sympathetic nerve function attainable using catecholamine radioisotope dilution analyses against a backdrop of the relative advantages and methodological limitations associated with the methodology.
Indexed as
Identifiers
16032382What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.