ArticleMolecular medicine (Cambridge, Mass.)
Molecular identification of simian virus 40 infection in healthy Italian subjects by birth cohort.
Article in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Association Between Simian Virus 40 and Human Tumors.Frontiers in oncology · 2019Review
- Viral microRNA effects on persistent infection of human lymphoid cells by polyomavirus SV40.PloS one · 2018Article
- Serum IgG Antibodies from Pregnant Women Reacting to Mimotopes of Simian Virus 40 Large T Antigen, the Viral Oncoprotein.Frontiers in immunology · 2017Article
- Specific Antibodies Reacting with SV40 Large T Antigen Mimotopes in Serum Samples of Healthy Subjects.PloS one · 2016Article
- Viral microRNA effects on pathogenesis of polyomavirus SV40 infections in syrian golden hamsters.PLoS pathogens · 2014Article
- Neutralizing and IgG antibodies against simian virus 40 in healthy pregnant women in Italy.PloS one · 2014Article
- Ethnic differences in polyomavirus simian virus 40 seroprevalence among women in Houston, Texas.The Journal of infection · 2013Article
- Influence of the viral regulatory region on tumor induction by simian virus 40 in hamsters.Journal of virology · 2008Article
- Simian virus 40 in humans.Infectious agents and cancer · 2007Article
- Mesothelioma mortality in Europe: impact of asbestos consumption and simian virus 40.Orphanet journal of rare diseases · 2006Article
- Role of simian virus 40 in cancer incidence in solid organ transplant patients.British journal of cancer · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Simian virus SV40, an oncogenic virus in rodents, was accidentally transmitted to humans through the Poliovirus vaccine during the years 1955 to 1963. If the vaccination program were the major source of human infection, then differences in SV40 infection rates by cohort of birth should be observed. The aim of this study was to address this issue. In 134 healthy Italian Caucasian subjects, 15 DNA samples were positive for SV40 by nested polymerase chain reaction and DNA sequencing. The prevalence of genomic infection did not differ across cohorts of birth from 1924 to 1983, however DNA sequencing revealed viral strain differences in individuals born before 1947 and after 1958. While horizontal transmission following the introduction of the polio vaccine could explain the presence of SV40 DNA in younger people, our results also suggest the possibility that other sources of the virus may also be involved in human SV40 infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.