ArticleJournal of bacteriology2005
NanA, a neuraminidase from Streptococcus pneumoniae, shows high levels of sequence diversity, at least in part through recombination with Streptococcus oralis.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 68 citations in OpenAlex.
- Relationships Between Oral Microecosystem and Respiratory Diseases.Frontiers in molecular biosciences · 2021Review
- Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood.Frontiers in cellular and infection microbiology · 2019Article
- Pherotype Polymorphism in Streptococcus pneumoniae Has No Obvious Effects on Population Structure and Recombination.Genome biology and evolution · 2017Article
- Pneumococcal Neuraminidase A (NanA) Promotes Biofilm Formation and Synergizes with Influenza A Virus in Nasal Colonization and Middle Ear Infection.Infection and immunity · 2017Article
- Streptococcus oralis Neuraminidase Modulates Adherence to Multiple Carbohydrates on Platelets.Infection and immunity · 2017Article
- Deacetylation of sialic acid by esterases potentiates pneumococcal neuraminidase activity for mucin utilization, colonization and virulence.PLoS pathogens · 2017Article
- Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization.Infection and immunity · 2016Article
- Discovery of prenylated flavonoids with dual activity against influenza virus and Streptococcus pneumoniae.Scientific reports · 2016Article
- Sequence diversity of NanA manifests in distinct enzyme kinetics and inhibitor susceptibility.Scientific reports · 2016Article
- Dual Acting Neuraminidase Inhibitors Open New Opportunities to Disrupt the Lethal Synergism between Streptococcus pneumoniae and Influenza Virus.Frontiers in microbiology · 2016Article
- Structural characterization of the carbohydrate-binding module of NanA sialidase, a pneumococcal virulence factor.BMC structural biology · 2015Article
- Mechanisms and impact of genetic recombination in the evolution of Streptococcus pneumoniae.Computational and structural biotechnology journal · 2015Review
- Involvement of aph(3')-IIa in the formation of mosaic aminoglycoside resistance genes in natural environments.Frontiers in microbiology · 2015Article
- Comparative Genomic Analyses of Streptococcus pseudopneumoniae Provide Insight into Virulence and Commensalism Dynamics.PloS one · 2013Article
- Differentiation of Streptococcus pneumoniae from nonpneumococcal streptococci of the Streptococcus mitis group by matrix-assisted laser desorption ionization-time of flight mass spectrometry.Journal of clinical microbiology · 2012Article
- Biofilm formation in Streptococcus pneumoniae.Microbial biotechnology · 2012Review
- Identification of a pheA gene associated with Streptococcus mitis by using suppression subtractive hybridization.Applied and environmental microbiology · 2012Article
- Article
- Contribution of serotype and genetic background to virulence of serotype 3 and serogroup 11 pneumococcal isolates.Infection and immunity · 2011Article
- Cell surface proteins in S. pneumoniae, S. mitis and S. oralis.Iranian journal of microbiology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus pneumoniae, an important human pathogen, contains at least two genes, nanA and nanB, that express sialidase activity. NanA is a virulence determinant of pneumococci which is important in animal models of colonization and middle ear infections. The gene encoding NanA was detected in all 106 pneumococcal strains screened that represented 59 restriction profiles. Sequencing confirmed a high level of diversity, up to 17.2% at the nucleotide level and 14.8% at the amino acid level. NanA diversity is due to a number of mechanisms including insertions, point mutations, and recombination generating mosaic genes. The level of nucleotide divergence for each recombinant block is greater than 30% and much higher than the 20% identified within mosaic pbp genes, suggesting that a high selective pressure exists for these alterations. These data indicate that at least one of the four recombinant blocks identified originated from a Streptococcus oralis isolate, demonstrating for the first time that protein virulence determinants of pneumococci have, as identified previously for genes encoding penicillin binding proteins, evolved by recombination with oral streptococci. No amino acid alterations were identified within the aspartic boxes or predicted active site, suggesting that sequence variation may be important in evading the adaptive immune response. Furthermore, this suggests that nanA is an important target of the immune system in the interaction between the pneumococcus and host.
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Registered trials
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