ArticleBlood2005
Functional avidity directs T-cell fate in autoreactive CD4+ T cells.
Article in Blood, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 62 citations in OpenAlex.
- Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis.Journal of immunology (Baltimore, Md. : 1950) · 2011Trial
- Heterogeneity and dynamics of DENV-specific CD8 + T cells in dengue infection.Nature communications · 2026Article
- NK cells reduce anergic T cell development in early-stage tumors by promoting myeloid cell maturation.Frontiers in oncology · 2022Article
- Optimization of a Method to Detect Autoantigen-Specific T-Cell Responses in Type 1 Diabetes.Frontiers in immunology · 2020Article
- The pursuit of transplantation tolerance: new mechanistic insights.Cellular & molecular immunology · 2019Article
- Low Avidity T Cells Do Not Hinder High Avidity T Cell Responses Against Melanoma.Frontiers in immunology · 2019Article
- Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8The Journal of experimental medicine · 2018Article
- Continuum model of T-cell avidity: Understanding autoreactive and regulatory T-cell responses in type 1 diabetes.Journal of theoretical biology · 2015Article
- Article
- T cell avidity and tumor immunity: problems and solutions.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2014Article
- Autoimmune responses in T1DM: quantitative methods to understand onset, progression, and prevention of disease.Pediatric diabetes · 2014Review
- Predictive models of type 1 diabetes progression: understanding T-cell cycles and their implications on autoantibody release.PloS one · 2014Article
- A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis.The Journal of experimental medicine · 2013Article
- Association of HLA-DRB1-restricted CD4⁺ T cell responses with HIV immune control.Nature medicine · 2013Article
- MHC class II tetramers made from isolated recombinant α and β chains refolded with affinity-tagged peptides.PloS one · 2013Article
- Production of primary human CD4⁺ T cell lines and clones.Methods in molecular biology (Clifton, N.J.) · 2013Article
- The pathogenesis and natural history of type 1 diabetes.Cold Spring Harbor perspectives in medicine · 2012Review
- CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity.Clinical and experimental immunology · 2012Article
- Molecular basis for T cell response induced by altered peptide ligand of type II collagen.The Journal of biological chemistry · 2012Article
- Characterization of inhibitory T cells induced by an analog of type II collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis.Arthritis research & therapy · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Major histocompatibility complex class II tetramer staining and activation analysis identified 2 distinct types of antigen-specific CD4+ T cells in the peripheral blood of humans with type 1 (autoimmune) diabetes. T cells with low-avidity recognition of peptide-MHC ligands had low sensitivity to activation and inefficient activation-induced apoptosis. In contrast, high-avidity T cells were highly sensitive to antigen-induced cell death through apoptotic mechanisms, and both apoptosis-resistant high- and low-avidity T cells that survived prolonged tetramer treatment were rendered anergic to restimulation by antigen. In addition, however, apoptosis-resistant high-avidity T cells acquired regulatory features, being able to suppress both antigen-specific and nonspecific CD4+ T-cell responses. This suppression was contact-dependent and correlated with the down-regulation of HLA class II and costimulatory molecules on antigen-presenting cells, including B cells and dendritic cells. T cells face a variety of fates following antigen exposure, including the paradoxic maintenance of high-avidity autoreactive T cells in the peripheral circulation, perhaps due to this capability of acquiring anergic and suppressive properties. Regulation via down-modulation of antigen-presenting cell function, a form of cell-to-cell licensing for suppression, also offers possibilities for the application of peptide-MHC therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.