ReviewBMC biology2005
Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genes.
Review in BMC biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
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- What role for AHR activation in IL4I1-mediated immunosuppression ?Oncoimmunology · 2021Article
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- Reciprocal Control of Thyroid Binding and the Pipecolate Pathway in the Brain.Neurochemical research · 2017Review
- Alterations of the immunosuppressive IL4I1 enzyme activity induced by naturally occurring SNP/mutations.Genes and immunity · 2016Article
- Lysine metabolism in mammalian brain: an update on the importance of recent discoveries.Amino acids · 2013Review
- Decoding pooled RNAi screens by means of barcode tiling arrays.BMC genomics · 2010Article
- Analysis of oligomeric proteins during unfolding by pH and temperature.Journal of molecular modeling · 2009Article
- Sense-antisense pairs in mammals: functional and evolutionary considerations.Genome biology · 2007Article
- CAFTAN: a tool for fast mapping, and quality assessment of cDNAs.BMC bioinformatics · 2006Article
- Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56,419 completely sequenced and manually annotated full-length cDNAs.Nucleic acids research · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGiven the complexity of higher organisms, the number of genes encoded by their genomes is surprisingly small. Tissue specific regulation of expression and splicing are major factors enhancing the number of the encoded products. Commonly these mechanisms are intragenic and affect only one gene.
resultsHere we provide evidence that the IL4I1 gene is specifically transcribed from the apparent promoter of the upstream NUP62 gene, and that the first two exons of NUP62 are also contained in the novel IL4I1_2 variant. While expression of IL4I1 driven from its previously described promoter is found mostly in B cells, the expression driven by the NUP62 promoter is restricted to cells in testis (Sertoli cells) and in the brain (e.g., Purkinje cells). Since NUP62 is itself ubiquitously expressed, the IL4I1_2 variant likely derives from cell type specific alternative pre-mRNA processing.
conclusionComparative genomics suggest that the promoter upstream of the NUP62 gene originally belonged to the IL4I1 gene and was later acquired by NUP62 via insertion of a retroposon. Since both genes are apparently essential, the promoter had to serve two genes afterwards. Expression of the IL4I1 gene from the "NUP62" promoter and the tissue specific involvement of the pre-mRNA processing machinery to regulate expression of two unrelated proteins indicate a novel mechanism of gene regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.