ArticleImmunogenetics2005
Haplotype characterization of transcribed ovine major histocompatibility complex (MHC) class I genes.
Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Uncovering novel MHC alleles from RNA-Seq data: expanding the spectrum of MHC class I alleles in sheep.BMC genomic data · 2023Article
- Comparative MHC nomenclature: report from the ISAG/IUIS-VIC committee 2018.Immunogenetics · 2018Article
- Structural and functional diversity arising from intra- and inter-haplotype combinations of duplicated DQA and B loci within the ovine MHC.Immunogenetics · 2018Article
- Immunological Homeostasis at the Ovine Placenta May Reflect the Degree of Maternal Fetal Interaction.Frontiers in immunology · 2018Article
- Article
- A comprehensive mapping of the structure and gene organisation in the sheep MHC class I region.BMC genomics · 2015Article
- MHC-DRB1/DQB1 Gene Polymorphism and Its Association with Resistance/Susceptibility to Cystic Echinococcosis in Chinese Merino Sheep.Journal of parasitology research · 2014Article
- Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K.Immunogenetics · 2013Article
- A physical map of a BAC clone contig covering the entire autosome insertion between ovine MHC Class IIa and IIb.BMC genomics · 2012Article
- Constraints on haplotype structure and variable gene frequencies suggest a functional hierarchy within cattle MHC class I.Immunogenetics · 2012Article
- Cattle MHC nomenclature: is it possible to assign sequences to discrete class I genes?Immunogenetics · 2012Article
- Genome-wide footprints of pig domestication and selection revealed through massive parallel sequencing of pooled DNA.PloS one · 2011Article
- A complete DNA sequence map of the ovine major histocompatibility complex.BMC genomics · 2010Article
- Analysis of MHC class I genes across horse MHC haplotypes.Immunogenetics · 2010Article
- Sequence-based genotyping of the sheep MHC class II DRB1 locus.Immunogenetics · 2010Article
- Genomic location and characterisation of nonclassical MHC class I genes in cattle.Immunogenetics · 2008Article
- Genetic and proteomic analysis of the MHC class I repertoire from four ovine haplotypes.Immunogenetics · 2008Article
- Genomic organisation and allelic diversity within coding and non-coding regions of the Ovar-DRB1 locus.Immunogenetics · 2008Article
- Generation and maintenance of diversity in the cattle MHC class I region.Immunogenetics · 2006Article
- Serological and molecular diversity in the cattle MHC class I region.Immunogenetics · 2005Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ovine major histocompatibility complex (MHC) remains poorly characterized compared with those of other livestock species. Molecular genetic analysis of the bovine MHC has revealed considerable haplotype and allelic diversity that earlier serological analysis had not detected. To develop cellular and molecular tools to support development of vaccines against intracellular pathogens of sheep, we have undertaken a molecular genetic analysis of four distinct ovine MHC haplotypes carried by two heterozygous Blackface rams. We have identified 12 novel class I transcripts and used a class I sequence-specific genotyping system to assign each of these transcripts to individual haplotypes. Using a combination of phylogenetic analysis, haplotype and transcript expression data, we identified at least four distinct polymorphic class I MHC loci, three of which appear together in a number of combinations in individual haplotypes. The haplotypes were further characterized at the highly polymorphic Ovar-DRB1 locus, allowing selection of the progeny of the two founder rams for the establishment of an MHC-defined resource population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.