Evidence map›Paper›PMID 16028027›Full record

ReviewSpringer seminars in immunopathology2005

Animal models of intestinal inflammation: ineffective communication between coalition members.

Robin G Lorenz, Vance J McCracken, Charles O Elson

Abstract readReview
PubMed Publisher
In one paragraph

Review in Springer seminars in immunopathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  10. From cheese to pharma: a designer probiotic for IBD.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2006
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Robin G LorenzDepartment of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Vance J McCracken
Charles O Elson
University of Alabama at Birmingham · US

Funding

Mucosal HIV and Immunobiology CenterR24DK064400 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SMITH, PHILLIP D · 2003 to 2012
$4.8M
TH2 CELLS DIRECT THE GENESIS OF COLONIC PATCHES AND IBDP01DK044240 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ELSON, CHARLES O · 1991 to 2003
$3.2M
INTESTINAL T-REGULATORY-1 CELLS IN MUCOSAL HOMEOSTASISR01DK060132 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ELSON, CHARLES O · 2002 to 2006
$1.4M
T Cell Initiated Gastric PathologyR01DK059911 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LORENZ, ROBINNA G. · 2003 to 2007
$1.4M
NIDDK NIH HHS DK064400NIDDK NIH HHS DK44240NIDDK NIH HHS DK59911NIDDK NIH HHS DK60132
6 · The paper itself

Abstract

The microbiota, epithelial cells, and mucosal immune cells in the intestine comprise an important gastrointestinal coalition. The intestinal microbiota can exert both beneficial as well as deleterious effects on their animal hosts. They interact with the innate defenses provided by epithelial cells through microbial recognition receptors. This communication, under normal conditions, results in a state of controlled inflammation. This article will focus on several animal models of intestinal inflammation, in which spontaneous or induced mutations or other genetic manipulations result in severe alterations in one of the members of the gastrointestinal coalition. These animal models of colitis have shown that alterations in communication between members of this coalition ultimately lead to gastrointestinal disease.

Indexed as

AnimalsBacteriaColitisCytokinesDisease Models, AnimalEpithelial CellsGastroenteritisImmunity, ActiveImmunity, InnateIntestinal MucosaIntestinesT-Lymphocyte SubsetsCytokines

Identifiers

PMID16028027
OpenAlexW2087974016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.