ArticlePlant molecular biology2005
Identification of a region of the Arabidopsis AtAOX1a promoter necessary for mitochondrial retrograde regulation of expression.
Article in Plant molecular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 92 citations in OpenAlex.
- Jasmonic acid plays an important role in mediating retrograde signaling under mitochondrial translational stress to balance plant growth and defense.Plant communications · 2025Article
- Perception and processing of stress signals by plant mitochondria.The Plant journal : for cell and molecular biology · 2024Review
- Mitochondrial ATP SynthaseInternational journal of molecular sciences · 2024Article
- Fine Tuning of ROS, Redox and Energy Regulatory Systems Associated with the Functions of Chloroplasts and Mitochondria in Plants under Heat Stress.International journal of molecular sciences · 2023Review
- CarrotPlants (Basel, Switzerland) · 2021Article
- The gene expression profiles of mitochondrial respiratory components in Arabidopsis plants with differing amounts ofPlant signaling & behavior · 2021Article
- Degradation of mitochondrial alternative oxidase in the appendices of Arum maculatum.The Biochemical journal · 2020Article
- The transcription factor ANAC017 is a key regulator of mitochondrial proteotoxic stress responses in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Ascorbate and Thiamin: Metabolic Modulators in Plant Acclimation Responses.Plants (Basel, Switzerland) · 2020Review
- Beyond Ethylene: New Insights Regarding the Role of Alternative Oxidase in the Respiratory Climacteric.Frontiers in plant science · 2020Review
- Communications Between the Endoplasmic Reticulum and Other Organelles During Abiotic Stress Response in Plants.Frontiers in plant science · 2019Review
- SnRK1 Kinase and the NAC Transcription Factor SOG1 Are Components of a Novel Signaling Pathway Mediating the Low Energy Response Triggered by ATP Depletion.Frontiers in plant science · 2019Article
- Article
- The Roles of Mitochondrial Reactive Oxygen Species in Cellular Signaling and Stress Response in Plants.Plant physiology · 2016Review
- Mitochondrial and Chloroplast Stress Responses Are Modulated in Distinct Touch and Chemical Inhibition Phases.Plant physiology · 2016Article
- Coordination of plant mitochondrial biogenesis: keeping pace with cellular requirements.Frontiers in plant science · 2014Review
- The membrane-bound NAC transcription factor ANAC013 functions in mitochondrial retrograde regulation of the oxidative stress response in Arabidopsis.The Plant cell · 2013Article
- A membrane-bound NAC transcription factor, ANAC017, mediates mitochondrial retrograde signaling in Arabidopsis.The Plant cell · 2013Article
- Mitochondrial energy and redox signaling in plants.Antioxidants & redox signaling · 2013Review
- AtWRKY40 and AtWRKY63 modulate the expression of stress-responsive nuclear genes encoding mitochondrial and chloroplast proteins.Plant physiology · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical inhibition of the mitochondrial electron transport chain (mtETC) by antimycin A (AA) or the TCA cycle by monofluoroacetate (MFA) causes increased expression of nucleus-encoded alternative oxidase (AOX) genes in plants. In order to better understand the mechanisms of this mitochondrial retrograde regulation (MRR) of gene expression, constructs containing deleted and mutated versions of a promoter region of the Arabidopsis thaliana AOX1a gene (AtAOX1a) controlling expression of the coding region of the enhanced firefly luciferase gene were employed to identify regions of the AtAOX1a promoter important for induction in response to mtETC or TCA cycle inhibition. Transient transformation coupled with in vitro and in vivo assays as well as plants containing transgenes with truncated promoter regions were used to identify a 93 base pair portion of the promoter, termed the MRR region, that was necessary for induction. Further mutational analyses showed that most of the 93 bp MRR region is important for both AA and MFA induction. Sub-regions within the MRR region that are especially important for strong induction by both AA or MFA were identified. Specific mutations in a W-box and Dof motifs in the MRR region indicate that these specific motifs are not important for induction. Recent evidence suggests that MRR of AOX genes following inhibition of the mtETC is via a separate signaling pathway from MRR resulting from metabolic shifts, such as those that result from MFA treatment. Our data suggest that these signaling pathways share regulatory regions in the AtAOX1a promoter. Arabidopsis proteins interacted specifically with a probe containing the MRR region, as shown by electrophoretic mobility shift assays and Southwestern blotting. These interactions were eliminated under reducing conditions.
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