Evidence map›Paper›PMID 16027737›Full record

ArticleMolecular psychiatry2005

Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene-environment interactions.

M D'Amelio, I Ricci, R Sacco, X Liu, L D'Agruma, L A Muscarella, V Guarnieri, R Militerni, C Bravaccio, M Elia and 9 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 125 citations in OpenAlex.

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  16. Environmental factors influencing the risk of autism.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017
    Review
  17. Lactonase Activity and Lipoprotein-Phospholipase AOxidative medicine and cellular longevity · 2017
    Article
  18. Bio-collections in autism research.Molecular autism · 2017
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 5 countries.

M D'AmelioLaboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio-Medico, Rome, Italy.
I Ricci
R Sacco
X Liu
L D'Agruma
L A Muscarella
V Guarnieri
R Militerni
C Bravaccio
M Elia
C Schneider
R Melmed
S Trillo
T Pascucci
S Puglisi-Allegra
K-L Reichelt
F Macciardi
J J A Holden
A M Persico
Casa Sollievo della Sofferenza · ITUniversità Campus Bio-Medico · ITFondazione Santa Lucia · ITQueen's University · CAUniversity of Naples Federico II · ITAssociazione Italiana Vulvodinia Onlus · ITCenter for Autism and Related Disorders · USI.R.C.C.S. Oasi Maria SS · ITSapienza University of Rome · ITSouthwest Autism Research & Resource Center · USUniversity of Oslo · NOUniversity of Toronto · CA

Funding

Telethon GGP02019
6 · The paper itself

Abstract

Organophosphates (OPs) are routinely used as pesticides in agriculture and as insecticides within the household. Our prior work on Reelin and APOE delineated a gene-environment interactive model of autism pathogenesis, whereby genetically vulnerable individuals prenatally exposed to OPs during critical periods in neurodevelopment could undergo altered neuronal migration, resulting in an autistic syndrome. Since household use of OPs is far greater in the USA than in Italy, this model was predicted to hold validity in North America, but not in Europe. Here, we indirectly test this hypothesis by assessing linkage/association between autism and variants of the paraoxonase gene (PON1) encoding paraoxonase, the enzyme responsible for OP detoxification. Three functional single nucleotide polymorphisms, PON1 C-108T, L55M, and Q192R, were assessed in 177 Italian and 107 Caucasian-American complete trios with primary autistic probands. As predicted, Caucasian-American and not Italian families display a significant association between autism and PON1 variants less active in vitro on the OP diazinon (R192), according to case-control contrasts (Q192R: chi2=6.33, 1 df, P<0.025), transmission/disequilibrium tests (Q192R: TDT chi2=5.26, 1 df, P<0.025), family-based association tests (Q192R and L55M: FBAT Z=2.291 and 2.435 respectively, P<0.025), and haplotype-based association tests (L55/R192: HBAT Z=2.430, P<0.025). These results are consistent with our model and provide further support for the hypothesis that concurrent genetic vulnerability and environmental OP exposure may possibly contribute to autism pathogenesis in a sizable subgroup of North American individuals.

Indexed as

AryldialkylphosphataseAutistic DisorderBase SequenceCase-Control StudiesChildDNADNA Mutational AnalysisEnvironmentFemaleGenetic VariationHumansInsecticidesItalyLinkage DisequilibriumMaleModels, BiologicalAryldialkylphosphataseDNAInsecticidesOrganophosphatesPeptidesPON1 protein, humanReelin ProteinRELN protein, humanSerotonin

Identifiers

PMID16027737
OpenAlexW2068923820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.