ArticleProceedings of the National Academy of Sciences of the United States of America2005
Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Generative Models of Brain Dynamics.Frontiers in artificial intelligence · 2022Review
- Stimulus Driven Functional Transformations in the Early Olfactory System.Frontiers in cellular neuroscience · 2021Article
- Feasibility of on/at Line Methods to Determine Boar Taint and Boar Taint Compounds: An Overview.Animals : an open access journal from MDPI · 2020Review
- A molecular odorant transduction model and the complexity of spatio-temporal encoding in the Drosophila antenna.PLoS computational biology · 2020Article
- Adaptive integrate-and-fire model reproduces the dynamics of olfactory receptor neuron responses in a moth.Journal of the Royal Society, Interface · 2019Article
- CaProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Mechanisms of regulation of olfactory transduction and adaptation in the olfactory cilium.PloS one · 2014Article
- Promising Aedes aegypti repellent chemotypes identified through integrated QSAR, virtual screening, synthesis, and bioassay.PloS one · 2013Article
- Common dynamical features of sensory adaptation in photoreceptors and olfactory sensory neurons.Scientific reports · 2013Article
- A dynamical feedback model for adaptation in the olfactory transduction pathway.Biophysical journal · 2012Article
- What is the core oscillator in the speract-activated pathway of the Strongylocentrotus purpuratus sperm flagellum?Biophysical journal · 2012Article
- A model of the intracellular response of an olfactory neuron in Caenorhabditis elegans to odor stimulation.PloS one · 2012Article
- Event timing in associative learning: from biochemical reaction dynamics to behavioural observations.PloS one · 2012Article
- Mathematical modeling of calcium signaling during sperm hyperactivation.Molecular human reproduction · 2011Review
- System identification of Drosophila olfactory sensory neurons.Journal of computational neuroscience · 2011Article
- Modelling and sensitivity analysis of the reactions involving receptor, G-protein and effector in vertebrate olfactory receptor neurons.Journal of computational neuroscience · 2009Article
- Modeling the response of a population of olfactory receptor neurons to an odorant.Journal of computational neuroscience · 2009Article
- Computational model of the insect pheromone transduction cascade.PLoS computational biology · 2009Article
- Collision coupling, crosstalk, and compartmentalization in G-protein coupled receptor systems: can a single model explain disparate results?Journal of theoretical biology · 2008Article
- Identification of Cl(Ca) channel distributions in olfactory cilia.Mathematical methods in the applied sciences · 2008Article
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3 authors.
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Abstract
We develop a mechanistic mathematical model of the G-protein coupled signaling pathway responsible for generating current responses in frog olfactory receptor neurons. The model incorporates descriptions of ligand-receptor interaction, intracellular transduction events involving the second messenger cAMP, effector ion-channel activity, and calcium-mediated feedback steps. We parameterized the model with respect to suction pipette current recordings from single cells stimulated with multiple odor concentrations. The proposed model accurately predicts the receptor-current response of the neuron to brief and prolonged odorant exposure and is able to produce the adaptation observed under repeated or sustained stimulation.
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