ArticleThe Journal of experimental medicine2005
CD4-CD8- T cells control intracellular bacterial infections both in vitro and in vivo.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 123 citations in OpenAlex.
- Article
- Evaluation of bacterial skin infections and difference analysis in T lymphocytes and inflammatory factors.Postepy dermatologii i alergologii · 2025Article
- QuilA® adjuvanted Coxevac® sustains Th1-CD8NPJ vaccines · 2023Article
- Effects of immunosuppressants on T-cell dynamics: Understanding from a generic coarse-grained immune network model.Journal of biosciences · 2022Review
- Host Immunity andMicroorganisms · 2021Review
- ExtrathymicScience immunology · 2021Article
- Differential Immune Response Following Intranasal and Intradermal Infection withMicroorganisms · 2021Review
- Early infection-induced natural antibody response.Scientific reports · 2021Article
- Hijacking of the Host's Immune Surveillance Radars byFrontiers in immunology · 2021Review
- Immune lymphocytes halt replication of Francisella tularensis LVS within the cytoplasm of infected macrophages.Scientific reports · 2020Article
- Diabetes alters immune response patterns to acute melioidosis in humans.European journal of immunology · 2019Article
- Review
- Glycoconjugate vaccine using a genetically modified O antigen induces protective antibodies toProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Distinct Features of Canine Non-conventional CD4Frontiers in immunology · 2019Article
- Oxidative Stress and Apoptotic Changes in Broiler Chicken Splenocytes Exposed to T-2 Toxin.BioMed research international · 2019Article
- Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner.PLoS pathogens · 2018Article
- Vaccine-Mediated Mechanisms Controlling Replication ofFrontiers in cellular and infection microbiology · 2018Article
- Complexity of type-specific 56 kDa antigen CD4 T-cell epitopes of Orientia tsutsugamushi strains causing scrub typhus in India.PloS one · 2018Article
- Adaptive Immunity toFrontiers in cellular and infection microbiology · 2018Review
- Concomitant Disruption ofJournal of immunology (Baltimore, Md. : 1950) · 2017Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory T cells, including the well-known CD4(+) and CD8(+) T cells, are central components of the acquired immune system and are the basis for successful vaccination. After infection, CD4(+) and CD8(+) T cells expand into effector cells, and then differentiate into long-lived memory cells. We show that a rare population of CD4(-)CD8(-)CD3(+)alphabeta(+)gammadelta(-)NK1.1(-) T cells has similar functions. These cells potently and specifically inhibit the growth of the intracellular bacteria Mycobacterium tuberculosis (M. tb.) or Francisella tularensis Live Vaccine Strain (LVS) in macrophages in vitro, promote survival of mice infected with these organisms in vivo, and adoptively transfer immunity to F. tularensis LVS. Furthermore, these cells expand in the spleens of mice infected with M. tb. or F. tularensis LVS, and then acquire a memory cell phenotype. Thus, CD4(-)CD8(-) T cells have a role in the control of intracellular infection and may contribute to successful vaccination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.