ArticleThe Journal of experimental medicine2005
Reciprocal regulation of airway rejection by the inducible gas-forming enzymes heme oxygenase and nitric oxide synthase.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Immunomodulatory Effects of Heme Oxygenase-1 in Kidney Disease.Frontiers in medicine · 2021Review
- CO-Releasing Materials: An Emphasis on Therapeutic Implications, as Release and Subsequent Cytotoxicity Are the Part of Therapy.Materials (Basel, Switzerland) · 2019Review
- Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.Nature communications · 2018Article
- Repurposing Tin Mesoporphyrin as an Immune Checkpoint Inhibitor Shows Therapeutic Efficacy in Preclinical Models of Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Article
- Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia.PloS one · 2018Article
- Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop.JCI insight · 2017Review
- Suppression of inflammatory cell trafficking and alveolar simplification by the heme oxygenase-1 product carbon monoxide.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Tumoral immune suppression by macrophages expressing fibroblast activation protein-α and heme oxygenase-1.Cancer immunology research · 2014Article
- Rattus model utilizing selective pulmonary ischemia induces bronchiolitis obliterans organizing pneumonia.Shock (Augusta, Ga.) · 2013Article
- Use of carbon monoxide in minimizing ischemia/reperfusion injury in transplantation.Transplantation reviews (Orlando, Fla.) · 2012Review
- Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression.Respiratory research · 2010Article
- The therapeutic potential of carbon monoxide.Nature reviews. Drug discovery · 2010Review
- Ecto-5'-nucleotidase (CD73) attenuates allograft airway rejection through adenosine 2A receptor stimulation.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Prevention of NSAID-Induced Small Intestinal Mucosal Injury: Prophylactic Potential of Lansoprazole.Journal of clinical biochemistry and nutrition · 2009Article
- Suppression of nitrosative and oxidative stress to reduce cardiac allograft vasculopathy.American journal of physiology. Heart and circulatory physiology · 2009Article
- The carbon monoxide-releasing molecule CORM-2 inhibits the inflammatory response induced by cytokines in Caco-2 cells.British journal of pharmacology · 2007Article
- The role of heme oxygenase-1 in pulmonary disease.American journal of respiratory cell and molecular biology · 2007Review
- Ketamine-induced gastroprotection during endotoxemia: role of heme-oxygenase-1.Digestive diseases and sciences · 2006Article
- Obligatory role for interleukin-13 in obstructive lesion development in airway allografts.The American journal of pathology · 2006Article
- Protective effect of carbon monoxide in transplantation.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Obliterative bronchiolitis (OB) develops insidiously in nearly half of all lung transplant recipients. Although typically preceded by a CD8(+) T cell-rich lymphocytic bronchitis, it remains unresponsive to conventional immunosuppression. Using an airflow permissive model to study the role of gases flowing over the transplanted airway, it is shown that prolonged inhalation of sublethal doses of carbon monoxide (CO), but not nitric oxide (NO), obliterate the appearance of the obstructive airway lesion. Induction of the enzyme responsible for the synthesis of CO, heme oxygenase (Hmox) 1, increased carboxyhemoglobin levels and suppressed lymphocytic bronchitis and airway luminal occlusion after transplantation. In contrast, zinc protoporphyrin IX, a competitive inhibitor of Hmox, increased airway luminal occlusion. Compared with wild-type allografts, expression of inducible NO synthase (iNOS), which promotes the influx of cytoeffector leukocytes and airway graft rejection, was strikingly reduced by either enhanced expression of Hmox-1 or exogenous CO. Hmox-1/CO decreased nuclear factor (NF)-kappaB binding activity to the iNOS promoter region and iNOS expression. Inhibition of soluble guanylate cyclase did not interfere with the ability of CO to suppress OB, implicating a cyclic guanosine 3',5'-monophosphate-independent mechanism through which CO suppresses NF-kappaB, iNOS transcription, and OB. Prolonged CO inhalation represents a new immunosuppresive strategy to prevent OB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.