ArticleThe Journal of cell biology2005
Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 70 citations in OpenAlex.
- Huntingtin-interacting protein 1 in cancer progression: a path less explored.Medical oncology (Northwood, London, England) · 2025Review
- Article
- The Role of Long Non-Coding RNAs in Epithelial-Mesenchymal Transition-Related Signaling Pathways in Prostate Cancer.Frontiers in molecular biosciences · 2022Review
- Adaptor protein APPL1 links neuronal activity to chromatin remodeling in cultured hippocampal neurons.Journal of molecular cell biology · 2021Article
- The long non-coding RNA PCAL7 promotes prostate cancer by strengthening androgen receptor signaling.Journal of clinical laboratory analysis · 2021Article
- Huntingtin-interacting protein family members have a conserved pro-viral function fromProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Androgen receptor co-regulation in prostate cancer.Asian journal of urology · 2020Review
- Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations.Cells · 2019Review
- Unconventional functions for clathrin, ESCRTs, and other endocytic regulators in the cytoskeleton, cell cycle, nucleus, and beyond: links to human disease.Cold Spring Harbor perspectives in biology · 2014Review
- Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.Nature medicine · 2014Article
- Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease.BMC genomics · 2014Article
- An integrative, translational approach to understanding rare and orphan genetically based diseases.Interface focus · 2013Article
- Therapeutic approaches to preventing cell death in Huntington disease.Progress in neurobiology · 2012Review
- Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.Physiological reviews · 2012Review
- Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: prediction and validation.BMC genomics · 2011Article
- Nuclear trafficking of the epidermal growth factor receptor family membrane proteins.Oncogene · 2010Review
- The endocytic matrix.Nature · 2010Review
- Transcription regulation of caspase-1 by R393 of HIPPI and its molecular partner HIP-1.Nucleic acids research · 2010Article
- Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex.The Biochemical journal · 2009Article
- Endocytic proteins in the regulation of nuclear signaling, transcription and tumorigenesis.Molecular oncology · 2009Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Internalization of activated receptors regulates signaling, and endocytic adaptor proteins are well-characterized in clathrin-mediated uptake. One of these adaptor proteins, huntingtin interacting protein 1 (HIP1), induces cellular transformation and is overexpressed in some prostate cancers. We have discovered that HIP1 associates with the androgen receptor through a central coiled coil domain and is recruited to DNA response elements upon androgen stimulation. HIP1 is a novel androgen receptor regulator, significantly repressing transcription when knocked down using a silencing RNA approach and activating transcription when overexpressed. We have also identified a functional nuclear localization signal at the COOH terminus of HIP1, which contributes to the nuclear translocation of the protein. In conclusion, we have discovered that HIP1 is a nucleocytoplasmic protein capable of associating with membranes and DNA response elements and regulating transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.