ArticleJournal of virology1992
Overexpression of the influenza virus polymerase can titrate out inhibition by the murine Mx1 protein.
Article in Journal of virology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Equine Mx1 Restricts Influenza A Virus Replication by Targeting at Distinct Site of its Nucleoprotein.Viruses · 2019Article
- Review
- Chemical-controlled Activation of Antiviral Myxovirus Resistance Protein 1.The Journal of biological chemistry · 2017Article
- To Conquer the Host, Influenza Virus Is Packing It In: Interferon-Antagonistic Strategies beyond NS1.Journal of virology · 2016Review
- Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import.Scientific reports · 2016Article
- Oligomerization and GTP-binding Requirements of MxA for Viral Target Recognition and Antiviral Activity against Influenza A Virus.The Journal of biological chemistry · 2015Article
- Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses.Journal of virology · 2015Article
- Mx proteins: antiviral gatekeepers that restrain the uninvited.Microbiology and molecular biology reviews : MMBR · 2013Review
- Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.PLoS pathogens · 2013Article
- Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly.Journal of virology · 2012Article
- Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49.The Journal of biological chemistry · 2011Article
- Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity.The Journal of biological chemistry · 2010Review
- Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase.Journal of virology · 2008Article
- NS1 proteins of avian influenza A viruses can act as antagonists of the human alpha/beta interferon response.Journal of virology · 2007Article
- Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections.Journal of virology · 2004Article
- Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome.Nucleic acids research · 2004Article
- MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes.Journal of virology · 2000Article
- Human MxA protein confers resistance to Semliki Forest virus and inhibits the amplification of a Semliki Forest virus-based replicon in the absence of viral structural proteins.Journal of virology · 1998Article
- Cloning of the rainbow trout (Oncorhynchus mykiss) Mx2 and Mx3 cDNAs and characterization of trout Mx protein expression in salmon cells.Journal of virology · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The murine Mx1 protein is an interferon-inducible protein which confers selective resistance to influenza virus infection both in vitro and in vivo. The precise mechanism by which the murine Mx1 specifically inhibits replication of influenza virus is not known. Previously, sensitive replication systems for influenza virus ribonucleoprotein, in which a synthetic influenza virus-like ribonucleoprotein is replicated and transcribed by influenza virus proteins provided in trans, have been developed. With these systems, the antiviral activity of the murine Mx1 protein was examined. It was found that continued expression of influenza polymerase polypeptides via vaccinia virus vectors can titrate out the inhibitory action of the murine Mx1 protein. This titration of inhibitory activity also occurs when the viral PB2 protein alone is overexpressed, suggesting that an antiviral target for the murine Mx1 polypeptide is the viral PB2 protein.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.