ArticleExperimental brain research2005
Inhibitory effect of amiloride and gadolinium on fine afferent nerves in the rat knee: evidence of mechanogated ion channels in joints.
Article in Experimental brain research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Innate Immunity at the Core of Sex Differences in Osteoarthritic Pain?Frontiers in pharmacology · 2022Review
- Mechanisms and Mediators That Drive Arthritis Pain.Current osteoporosis reports · 2015Review
- Ion channels and osteoarthritic pain: potential for novel analgesics.Current pain and headache reports · 2013Review
- Towards a mechanism-based approach to pain management in osteoarthritis.Nature reviews. Rheumatology · 2013Review
- A commentary on modelling osteoarthritis pain in small animals.Osteoarthritis and cartilage · 2013Review
- Neurosensory mechanotransduction through acid-sensing ion channels.Journal of cellular and molecular medicine · 2013Review
- Involvement of Nav 1.8 sodium ion channels in the transduction of mechanical pain in a rodent model of osteoarthritis.Arthritis research & therapy · 2012Article
- Understanding sensory nerve mechanotransduction through localized elastomeric matrix control.PloS one · 2009Article
- Age alters the ability of substance P to sensitize joint nociceptors in guinea pigs.Journal of molecular neuroscience : MN · 2007Article
- Arthritis and pain. Neurogenic origin of joint pain.Arthritis research & therapy · 2006Review
- Osteoarthritis is a neurological disease - an hypothesis.Osteoarthritis and cartilage openReview
- The contribution of clock genes BMAL1 and PER2 in osteoarthritis-associated pain.Neurobiology of pain (Cambridge, Mass.)Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synovial joints are complex sensory organs which provide continuous feedback regarding position sense and degree of limb movement. The transduction mechanisms which convert mechanical forces acting on the joint into an electrochemical signal which can then be transmitted to the central nervous system are not well understood. The present investigation examined the effect of the mechanogated ion channel blockers amiloride and gadolinium on knee joint mechanosensitivity. In deeply anaesthetised rats (sodium thiopental: 100-120 mg/kg, i.p.), single unit extracellular recordings were made from knee joint group III (Adelta) and group IV (C) primary afferents in response to mechanical rotation of the joint. Afferent firing rate was measured before and after topical application of either amiloride (0.1 mM, 1 mM) or gadolinium (250 microM) onto the receptive field of the sensory unit and recording was continued every 10 min up to a total of 50 min. With normal rotation of the knee, joint mechanosensitivity was significantly reduced by both amiloride (P<0.0001; n=10-21) and gadolinium (P=0.001; n=12) and this effect was sustained throughout the recording period. This investigation provides the first in vivo electrophysiological evidence that joint mechanotransduction involves the activation of amiloride and gadolinium-sensitive mechanogated ion channels. Future studies to determine the mechanogated ion channel subtypes present in joints and the modulation of their gating properties during inflammation may yield novel approaches for the control of arthritis pain.
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