ArticleThe Journal of clinical investigation2005
Induction of prolonged survival of CD4+ T lymphocytes by intermittent IL-2 therapy in HIV-infected patients.
Article in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00559416 (Immunologic and Virologic Response in HIV Infected Progressors After Infusion of Lymphocytes From HIV Infected "Elite" Long-Term Non-Progressors), which is not on this map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Immunologic and Virologic Response in HIV Infected Progressors After Infusion of Lymphocytes From HIV Infected "Elite" Long-Term Non-Progressors
Who cites it
51 citing papers in PubMed, 123 citations in OpenAlex.
- T cell functionality in HIV-1, HIV-2 and dually infected individuals: correlates of disease progression and immune restoration.Clinical and experimental immunology · 2019Trial
- Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Trial
- Long-term effects of intermittent IL-2 in HIV infection: extended follow-up of the INSIGHT STALWART Study.PloS one · 2012Trial
- The effect of intermittent IL-2 therapy on CD4 T cells in the gut in HIV-1-infected patients.Journal of acquired immune deficiency syndromes (1999) · 2011Trial
- Effects of intermittent IL-2 alone or with peri-cycle antiretroviral therapy in early HIV infection: the STALWART study.PloS one · 2010Trial
- Interleukin-2 therapy in patients with HIV infection.The New England journal of medicine · 2009Trial
- Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption: a randomized controlled trial.AIDS (London, England) · 2009Trial
- Elucidating the Gene Signatures and Immune Cell Types in HIV-Infected Immunological Non-Responders by Bioinformatics Analyses.International journal of general medicine · 2022Article
- SARS-CoV-2 and Human Immunodeficiency Virus: Pathogen Pincer Attack.HIV/AIDS (Auckland, N.Z.) · 2021Review
- Characterizing the Latent HIV-1 Reservoir in Patients with Viremia Suppressed on cART: Progress, Challenges, and Opportunities.Current HIV research · 2020Article
- Cat and Mouse: HIV Transcription in Latency, Immune Evasion and Cure/Remission Strategies.Viruses · 2019Review
- Immune signatures for HIV-1 and HIV-2 induced CD4BMC infectious diseases · 2019Article
- Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung.Stem cells international · 2019Article
- Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections.PLoS pathogens · 2018Article
- Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 Infections.Frontiers in immunology · 2017Review
- Diversity of HIV-1 reservoirs in CD4+ T-cell subpopulations.Current opinion in HIV and AIDS · 2016Review
- Analysis of Th17 and Tc17 Frequencies and Antiviral Defenses in Gut-Associated Lymphoid Tissue of Chronic HIV-1 Positive Patients.Mediators of inflammation · 2015Article
- Article
- Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.PLoS computational biology · 2014Article
- Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.PLoS pathogens · 2014Article
Corrections and comments
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Authors and funding
24 authors at 3 institutions in 1 country.
Funding
Abstract
HIV infection leads to decreases in the number of CD4 T lymphocytes and an increased risk for opportunistic infections and neoplasms. The administration of intermittent cycles of IL-2 to HIV-infected patients can lead to profound increases (often greater than 100%) in CD4 cell number and percentage. Using in vivo labeling with 2H-glucose and BrdU, we have been able to demonstrate that, although therapy with IL-2 leads to high levels of proliferation of CD4 as well as CD8 lymphocytes, it is a remarkable preferential increase in survival of CD4 cells (with half-lives that can exceed 3 years) that is critical to the sustained expansion of these cells. This increased survival was time-dependent: the median half-life, as determined by semiempirical modeling, of labeled CD4 cells in 6 patients increased from 1.7 weeks following an early IL-2 cycle to 28.7 weeks following a later cycle, while CD8 cells showed no change in the median half-life. Examination of lymphocyte subsets demonstrated that phenotypically naive (CD27+CD45RO-) as well as central memory (CD27+CD45RO+) CD4 cells were preferentially expanded, suggesting that IL-2 can help maintain cells important for host defense against new antigens as well as for long-term memory to opportunistic pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.