ArticleThe British journal of ophthalmology2005
Multifocal ERG in ethambutol associated visual loss.
Article in The British journal of ophthalmology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Longitudinal evaluation of visual function and structure for detection of subclinical Ethambutol-induced optic neuropathy.PloS one · 2019Trial
- Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity.Biomolecules · 2022Review
- Ethambutol toxicity: Expert panel consensus for the primary prevention, diagnosis and management of ethambutol-induced optic neuropathy.Indian journal of ophthalmology · 2021Article
- Visual electrophysiology in the assessment of toxicity and deficiency states affecting the visual system.Eye (London, England) · 2021Review
- Spectrum and Clinical Course of Visual Field Abnormalities in Ethambutol Toxicity.Neuro-ophthalmology (Aeolus Press) · 2016Article
- Ethambutol induces impaired autophagic flux and apoptosis in the rat retina.Disease models & mechanisms · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the anatomical site and extent of electrophysiological dysfunction in patients with ethambutol associated visual loss.
methodsA comparative case series. Four patients with ethambutol associated visual loss underwent multifocal electroretinography (mERG). Two patients had advanced visual loss while two had early signs of toxicity. The N1-P1, N1, P1 amplitudes, N1, and P1 latencies were compared to 10 age and sex matched controls.
resultsmERG abnormalities were detected in the ethambutol treated patients. The N1 amplitude was significantly lower in the ethambutol treated patients than in the control group.
conclusionEthambutol is possibly toxic to the retina, and not only the optic nerve. The multifocal ERG may be of value to diagnose and monitor patients taking ethambutol.
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